{"id":"W2104128007","doi":"10.1128/ec.05025-11","title":"Characterization, Localization, Essentiality, and High-Resolution Crystal Structure of Glucosamine 6-Phosphate <i>N</i> -Acetyltransferase from Trypanosoma brucei","year":2011,"lang":"en","type":"article","venue":"Eukaryotic Cell","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Trypanosoma brucei; Biology; Glycosylation; Biochemistry; Acetyltransferase; Mutant; Trypanosoma; Glucosamine; Glycoprotein; Transferase; Escherichia coli; Molecular biology; Gene; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724829,0.0003076237,0.0002585822,0.0001429558,0.0002528813,0.0005070441,0.0004340318,0.0003409357,0.0004221077],"category_scores_gemma":[0.0004779206,0.0002465998,0.0001893944,0.0003538462,0.0002007984,0.0001899172,0.0001415193,0.0007446148,0.0003266406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008492335,"about_ca_system_score_gemma":0.0005106878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004178579,"about_ca_topic_score_gemma":0.004537352,"domain_scores_codex":[0.9999081,0.00001532058,0.000008979154,0.00001579012,0.00003811879,0.00001373488],"domain_scores_gemma":[0.9998307,0.00003814286,0.00003784787,0.00001316279,0.00003414776,0.00004578413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001870612,0.00008563118,0.001369484,0.0001316902,0.00001426136,0.0003751401,0.0001260147,0.001068604,0.9929283,0.0004266507,0.0004994559,0.002787774],"study_design_scores_gemma":[0.0002771796,0.0004420834,0.02723682,0.00006076772,0.00009841673,0.002581432,0.0003459133,0.01845706,0.9254713,0.000662253,0.02432329,0.00004347519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916117,0.002469026,0.002432668,0.0004927979,0.00004211364,0.00003212691,0.001181077,0.00005296473,0.001685388],"genre_scores_gemma":[0.9724368,0.003142026,0.01262769,0.000147978,0.0000272547,0.00004837446,0.008800012,0.00005773432,0.002712176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004178579,"threshold_uncertainty_score":0.00830853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01375740648234766,"score_gpt":0.2247620311657694,"score_spread":0.2110046246834218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}