{"id":"W2104192439","doi":"10.1158/1078-0432.ccr-06-0089","title":"Strategies to Enhance Epidermal Growth Factor Inhibition: Targeting the Mevalonate Pathway","year":2006,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Ottawa Regional Cancer Foundation; University of Ottawa","funders":"","keywords":"Lovastatin; Gefitinib; Mevalonate pathway; Epidermal growth factor receptor; Pharmacology; Erlotinib; HMG-CoA reductase; Tyrosine-kinase inhibitor; Cancer research; EGFR inhibitors; CYP3A4; Signal transduction; Reductase; Biology; Chemistry; Cancer; Medicine; Endocrinology; Biochemistry; Internal medicine; Receptor; Cholesterol; Enzyme; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003520291,0.0007580919,0.000579604,0.0007229159,0.0001826388,0.0007453592,0.0004991436,0.0005840203,0.001563645],"category_scores_gemma":[0.0001736941,0.0002290127,0.0006335456,0.0003471068,0.0002349261,0.000597057,0.0004363706,0.001213205,0.0005539049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000494234,"about_ca_system_score_gemma":0.0002770329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007500366,"about_ca_topic_score_gemma":0.001903764,"domain_scores_codex":[0.9997798,0.0000434682,0.00001274534,0.00004051628,0.00006399139,0.00005951039],"domain_scores_gemma":[0.9999101,0.00001745718,0.00002390759,0.000008847275,0.00002019853,0.00001948983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000414081,0.0005550478,0.0002587544,0.0007906248,0.0001115567,0.0002659466,0.00007350254,0.001220442,0.9318286,0.001236058,0.001179479,0.06206597],"study_design_scores_gemma":[0.0004465988,0.005474915,0.003462026,0.0001131467,0.0003253691,0.001526574,0.0001023956,0.003536311,0.8814681,0.001054882,0.1024387,0.00005108224],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7114174,0.1696976,0.08895265,0.004527353,0.001057679,0.001439894,0.0009724455,0.001077169,0.02085777],"genre_scores_gemma":[0.8933614,0.06444458,0.03135797,0.001068818,0.0001742453,0.000359394,0.0005964463,0.0000826667,0.00855449],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001563645,"threshold_uncertainty_score":0.005230904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1651094382414635,"score_gpt":0.5140349773078748,"score_spread":0.3489255390664113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}