{"id":"W2104258504","doi":"10.1345/aph.1m393","title":"Drug-Drug Interaction Between Itraconazole and the Protease Inhibitor Lopinavir/Ritonavir","year":2009,"lang":"en","type":"article","venue":"Annals of Pharmacotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Alberta Health Services","funders":"","keywords":"Itraconazole; Lopinavir; Ritonavir; Medicine; Efavirenz; Pharmacology; Lopinavir/ritonavir; Gastroenterology; Internal medicine; Immunology; Dermatology; Antifungal; Human immunodeficiency virus (HIV); Antiretroviral therapy; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000617466,0.0004324408,0.0005597936,0.0004563198,0.0003251235,0.0004719095,0.000293019,0.0005861335,0.001065437],"category_scores_gemma":[0.002179725,0.0001221525,0.000499546,0.0003729176,0.0002125827,0.0003313961,0.0002099089,0.0005690597,0.0003402227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002628258,"about_ca_system_score_gemma":0.0002209484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004482626,"about_ca_topic_score_gemma":0.0006802506,"domain_scores_codex":[0.9986877,0.0003493661,0.0001573399,0.0001720851,0.0005056584,0.0001278201],"domain_scores_gemma":[0.998744,0.000501467,0.0004598566,0.00006350993,0.0001231458,0.0001080178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003493529,0.001357724,0.616214,0.0004564441,0.0007165147,0.09426185,0.0005944425,0.001651993,0.1407712,0.0001611783,0.00169698,0.1386242],"study_design_scores_gemma":[0.0003304619,0.01624984,0.5083084,0.000158138,0.001641478,0.2813837,0.0004875263,0.0153283,0.1584753,0.0002444472,0.01728285,0.0001094603],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920026,0.004070256,0.001142168,0.0002558251,0.00003701345,0.00005082332,0.00009870349,0.00007229777,0.002270382],"genre_scores_gemma":[0.9979597,0.0005386526,0.0008092088,0.0002093342,0.00005304937,0.000008185394,0.0001087965,0.0000088315,0.0003042225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001065437,"threshold_uncertainty_score":0.003564239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05014064385374683,"score_gpt":0.3967659695904373,"score_spread":0.3466253257366904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}