{"id":"W2104293217","doi":"10.1016/j.stem.2013.01.018","title":"Short Telomeres in ESCs Lead to Unstable Differentiation","year":2013,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Wellcome Trust","keywords":"Biology; Telomere; Homeobox protein NANOG; Leukemia inhibitory factor; Cellular differentiation; Epigenetics; Rex1; Embryonic stem cell; Cell biology; Stem cell; Small hairpin RNA; DNA methylation; Induced pluripotent stem cell; Genome instability; Genetics; Gene knockdown; DNA damage; Cell culture; Gene expression; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008924895,0.0001227538,0.0001082728,0.00005908564,0.0000363155,0.00004038119,0.0001199816,0.0001196145,0.00005009409],"category_scores_gemma":[0.000003603022,0.0001198952,0.00004080764,0.0001007089,0.00001131003,0.000004446787,0.00007056283,0.00005590461,0.0001480534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001849578,"about_ca_system_score_gemma":0.00001773139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007172305,"about_ca_topic_score_gemma":0.00006335349,"domain_scores_codex":[0.9991473,0.00004082563,0.000198001,0.0002832757,0.000101585,0.0002289912],"domain_scores_gemma":[0.9995672,0.000009152252,0.00003447683,0.0002528567,0.00005531264,0.00008098192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006363756,0.00006568405,0.02189218,0.0000244883,0.000002583545,4.064812e-7,0.00005721827,0.0003602695,0.968024,0.000003652319,0.0005533578,0.009009815],"study_design_scores_gemma":[0.0001851219,0.0001000147,0.02923711,0.00000566862,0.000004592926,9.856876e-8,0.00009235217,0.0002003651,0.9608411,0.00003784455,0.009134689,0.0001610223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835321,0.001114024,0.0024613,0.00003577956,0.0001311848,0.0003183893,0.000003277963,0.000008059758,0.01239583],"genre_scores_gemma":[0.9928671,0.0001923011,0.0003673434,0.00005437492,0.00007494449,0.00004193981,0.00007119821,0.00002019037,0.006310571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009334981,"threshold_uncertainty_score":0.4889183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009625317505466647,"score_gpt":0.2175971223255133,"score_spread":0.2079718048200467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}