{"id":"W2104293217","doi":"10.1016/j.stem.2013.01.018","title":"Short Telomeres in ESCs Lead to Unstable Differentiation","year":2013,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Wellcome Trust","keywords":"Biology; Telomere; Homeobox protein NANOG; Leukemia inhibitory factor; Cellular differentiation; Epigenetics; Rex1; Embryonic stem cell; Cell biology; Stem cell; Small hairpin RNA; DNA methylation; Induced pluripotent stem cell; Genome instability; Genetics; Gene knockdown; DNA damage; Cell culture; Gene expression; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000266242,0.0003523472,0.0002791252,0.0004032537,0.0001586338,0.0003967588,0.0002058845,0.0004009166,0.001326793],"category_scores_gemma":[0.0003355433,0.0002175283,0.0003652605,0.000240469,0.0002494489,0.0002147405,0.0005225173,0.0006892758,0.0007488079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002457333,"about_ca_system_score_gemma":0.0001477449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002987358,"about_ca_topic_score_gemma":0.0005221589,"domain_scores_codex":[0.9997299,0.00004553055,0.00006412747,0.00004179326,0.00008292051,0.00003570794],"domain_scores_gemma":[0.9996271,0.0000723096,0.0001285118,0.00007038078,0.00003952279,0.0000621513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002812735,0.000005209074,0.0003904545,0.00001678208,0.000007576195,0.0001293268,0.00001155415,0.00008958106,0.9982004,0.0001632621,0.00002789457,0.0009297158],"study_design_scores_gemma":[0.0000144419,0.0001588129,0.007811729,0.00001425666,0.00003898724,0.00125408,0.00003958296,0.001390292,0.9859105,0.0002915951,0.003065522,0.00001002991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890243,0.00170612,0.007049781,0.0001045824,0.00005427158,0.00001934083,0.000528669,0.0001635891,0.001349367],"genre_scores_gemma":[0.9944817,0.0006689645,0.001691545,0.00006705552,0.00001135473,0.00001921906,0.0006427769,0.00006550756,0.002351911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001326793,"threshold_uncertainty_score":0.004438579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009625317505466647,"score_gpt":0.2175971223255133,"score_spread":0.2079718048200467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}