{"id":"W2104318220","doi":"10.1093/intimm/dxl003","title":"Increased negative selection impairs neonatal B cell repertoire but does not directly lead to generation of disease-associated IgM auto-antibodies","year":2006,"lang":"en","type":"article","venue":"International Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Antibody; Molecular biology; Biology; Gene; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001279645,0.0003230744,0.0002090608,0.0001626495,0.00007187617,0.0002545124,0.0002477978,0.0002583459,0.001823764],"category_scores_gemma":[0.0002917581,0.0001259826,0.0001546315,0.00006092159,0.0001977384,0.0001655058,0.0002486579,0.000514697,0.0002883485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001877349,"about_ca_system_score_gemma":0.0001051671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003274672,"about_ca_topic_score_gemma":0.0003902358,"domain_scores_codex":[0.9997521,0.00004043633,0.00002239048,0.00005885247,0.0000623025,0.00006389528],"domain_scores_gemma":[0.9996266,0.00009350701,0.000101099,0.00004509891,0.00002626094,0.0001074727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007411476,0.00001168845,0.0007658302,0.00001034029,0.000002270812,0.00008763705,0.000007593166,0.00001544585,0.9984101,0.00002371119,0.000008343933,0.0005829035],"study_design_scores_gemma":[0.00001295147,0.000750838,0.04182816,0.00001081726,0.0000178445,0.002201207,0.00007200153,0.0003934733,0.9537019,0.00005072898,0.0009554382,0.000004658014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989091,0.0002618361,0.0003201481,0.00001396775,0.000005219497,0.00000271494,0.00005871588,0.00001460293,0.0004135193],"genre_scores_gemma":[0.9978521,0.0001860776,0.0003298746,0.00002713844,0.000005211548,0.00001065809,0.0002243183,0.00001575998,0.00134877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001823764,"threshold_uncertainty_score":0.006101072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009153446692481037,"score_gpt":0.2249214003763434,"score_spread":0.2157679536838624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}