{"id":"W2104337076","doi":"10.1017/s0007114514003717","title":"Effect of a high-fat diet on the hepatic expression of nuclear receptors and their target genes: relevance to drug disposition","year":2015,"lang":"en","type":"article","venue":"British Journal Of Nutrition","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; King Abdulaziz University","keywords":"Pregnane X receptor; Constitutive androstane receptor; Nuclear receptor; Internal medicine; Endocrinology; Farnesoid X receptor; Receptor; Liver X receptor; Biology; ABCA1; Gene expression; Multidrug resistance-associated protein 2; Transporter; Medicine; Gene; ATP-binding cassette transporter; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006713567,0.0001000241,0.0004071656,0.00008985117,0.00004161315,0.00001718086,0.00007293766,0.00005156956,0.00001847323],"category_scores_gemma":[0.0003487643,0.00006880957,0.0001012433,0.0001200908,0.00005582445,0.0001349182,0.0000227625,0.0001812295,0.000001989392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003337022,"about_ca_system_score_gemma":0.00001252607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004036193,"about_ca_topic_score_gemma":0.00000244442,"domain_scores_codex":[0.9988418,0.000270997,0.0003841567,0.000104946,0.0002967514,0.0001014031],"domain_scores_gemma":[0.9990348,0.0001980622,0.0002922707,0.0001123654,0.0002191531,0.0001433682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01953437,0.002566248,0.00172217,0.001976837,0.0001304754,0.0001011617,0.003516667,0.00004939724,0.7068388,0.0000955823,0.07177384,0.1916944],"study_design_scores_gemma":[0.01856742,0.01966646,0.03100607,0.03558347,0.0003619793,0.001953584,0.001690072,0.0001536836,0.8601125,0.001834774,0.02871191,0.0003581003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946365,0.003563821,0.00008124221,0.0009957951,0.0003186563,0.0003460526,0.00002425349,0.000006480547,0.00002722322],"genre_scores_gemma":[0.9970259,0.001654187,0.00063888,0.0001635852,0.0004647208,0.000007250399,0.000008719963,0.00001703,0.00001970281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1913363,"threshold_uncertainty_score":0.2805973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008009692666442665,"score_gpt":0.2305473504116444,"score_spread":0.2225376577452018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}