{"id":"W2104367238","doi":"10.1016/j.bbamcr.2008.04.005","title":"Smad signaling pathway is a pivotal component of tissue inhibitor of metalloproteinases-3 regulation by transforming growth factor beta in human chondrocytes","year":2008,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Arthritis Network; Canadian Institutes of Health Research","keywords":"SMAD; Gene knockdown; Smad2 Protein; Chromatin immunoprecipitation; Small interfering RNA; Cell biology; Transforming growth factor beta; Signal transduction; Transforming growth factor; Matrix metalloproteinase; Phosphorylation; Biology; Molecular biology; R-SMAD; Chemistry; Promoter; Gene expression; Gene; Transfection; Endoglin; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001434849,0.0003984342,0.0002074566,0.0003214862,0.0002679183,0.000347038,0.0001425301,0.0001923725,0.002192354],"category_scores_gemma":[0.0001182402,0.0002331876,0.0004117849,0.0001404248,0.0002084472,0.0001902302,0.000206341,0.0004390888,0.0005317321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002072522,"about_ca_system_score_gemma":0.0004118246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007247954,"about_ca_topic_score_gemma":0.001203356,"domain_scores_codex":[0.9998794,0.00001756349,0.000008710722,0.00001698021,0.00003850835,0.00003890169],"domain_scores_gemma":[0.9999229,0.000009028186,0.00002142207,0.000005504617,0.00001798231,0.00002316949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005224636,0.00002754856,0.001124645,0.0001173402,0.00001637554,0.0003731021,0.00004520703,0.00005448481,0.9945971,0.0003929076,0.0001239554,0.002604811],"study_design_scores_gemma":[0.0001573981,0.0004219357,0.07874354,0.00003734058,0.000149727,0.002196702,0.0003189395,0.001372464,0.9069286,0.0004830293,0.009169958,0.00002038697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760876,0.01063387,0.006360275,0.0003466515,0.000124718,0.00006535235,0.00104474,0.0001169907,0.005219769],"genre_scores_gemma":[0.9899493,0.002490029,0.001789179,0.00006577186,0.00002796061,0.0000399934,0.0008608598,0.00001241477,0.004764482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002192354,"threshold_uncertainty_score":0.007334113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0279276473872372,"score_gpt":0.2965097617289564,"score_spread":0.2685821143417192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}