{"id":"W2104378519","doi":"10.3389/fphar.2012.00019","title":"Left-Shifted Nav Channels in Injured Bilayer: Primary Targets for Neuroprotective Nav Antagonists?","year":2012,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Sodium channel; Biophysics; Chemistry; Axon; Bilayer; Neurotoxin; Neuroprotection; Membrane potential; Ion channel; Electrophysiology; Neuroscience; Pharmacology; Membrane; Medicine; Biochemistry; Biology; Sodium; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002243421,0.0005027647,0.0009967164,0.0002224656,0.0002140199,0.0006667696,0.0004777439,0.0006544268,0.002221498],"category_scores_gemma":[0.0001740922,0.000195339,0.0003257127,0.0001131669,0.000312826,0.0007842328,0.0001856839,0.0007776001,0.0009827146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002803884,"about_ca_system_score_gemma":0.0002713017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003167439,"about_ca_topic_score_gemma":0.0009227932,"domain_scores_codex":[0.9999121,0.00001387903,0.000005719753,0.00001676109,0.00001211954,0.00003934243],"domain_scores_gemma":[0.9999298,0.000009471355,0.00001797253,0.000006733249,0.0000211171,0.00001493607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001128878,0.0002935908,0.0005652847,0.0005321116,0.00003365988,0.000391608,0.0001157094,0.000297952,0.949499,0.001616291,0.001095726,0.04443026],"study_design_scores_gemma":[0.0004539958,0.007315709,0.006268714,0.0001996903,0.0002633022,0.002373477,0.0004155164,0.00371079,0.9448314,0.003100812,0.03100398,0.00006252128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8647401,0.09682122,0.01975785,0.005087002,0.0004558009,0.0005802072,0.0005884675,0.0005958824,0.01137335],"genre_scores_gemma":[0.9421108,0.044059,0.006741137,0.001361084,0.0003019813,0.0002225868,0.000298199,0.00006151514,0.004843649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002221498,"threshold_uncertainty_score":0.007431626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01110358830443113,"score_gpt":0.2707663299693592,"score_spread":0.259662741664928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}