{"id":"W2104382557","doi":"10.1038/nature11401","title":"FTO genotype is associated with phenotypic variability of body mass index","year":2012,"lang":"en","type":"review","venue":"Nature","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":455,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Ontario Institute for Cancer Research","funders":"National Center for Research Resources; U.S. National Library of Medicine; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; Cancer Research UK; National Health and Medical Research Council; National Human Genome Research Institute; Wellcome Trust; Australian Research Council; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; National Institutes of Health","keywords":"Biology; Single-nucleotide polymorphism; Genetics; Genetic variation; Phenotype; Quantitative trait locus; Genome-wide association study; Genotype; Locus (genetics); Genetic association; Genetic variability; Trait; SNP; Genetic architecture; Evolutionary biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005201254,0.0007528896,0.001179426,0.0009325151,0.000139809,0.000679761,0.0005772135,0.0008466512,0.001193504],"category_scores_gemma":[0.001264309,0.0001866198,0.0003498586,0.001273722,0.0004708468,0.0004160578,0.0003347257,0.0009605236,0.0003751272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003415362,"about_ca_system_score_gemma":0.0005742271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002024852,"about_ca_topic_score_gemma":0.002470934,"domain_scores_codex":[0.9998367,0.00002772495,0.00002303133,0.00005806228,0.0000432756,0.00001126226],"domain_scores_gemma":[0.9993621,0.0004017905,0.0001111635,0.00001625676,0.00007940951,0.00002928688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003007612,0.00007249748,0.0139669,0.004086438,0.0004638107,0.0005417351,0.00003998586,0.0003386014,0.001578033,0.002429642,0.01386614,0.9623154],"study_design_scores_gemma":[0.0001192875,0.0002948729,0.1330937,0.007549215,0.002801647,0.01236704,0.0002638819,0.0009613181,0.002259844,0.01625558,0.8238828,0.0001508459],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00142395,0.9958512,0.0006000306,0.0009056001,0.0002399174,0.000002723428,0.00008626471,0.00001131269,0.000879037],"genre_scores_gemma":[0.009591324,0.9872617,0.0008391606,0.0005267634,0.0008805477,0.00001019004,0.0001291257,0.000004330623,0.000756881],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002024852,"threshold_uncertainty_score":0.004026115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01518852313628676,"score_gpt":0.2959499182822947,"score_spread":0.2807613951460079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}