{"id":"W2104382557","doi":"10.1038/nature11401","title":"FTO genotype is associated with phenotypic variability of body mass index","year":2012,"lang":"en","type":"review","venue":"Nature","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":455,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Ontario Institute for Cancer Research","funders":"National Center for Research Resources; U.S. National Library of Medicine; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; Cancer Research UK; National Health and Medical Research Council; National Human Genome Research Institute; Wellcome Trust; Australian Research Council; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; National Institutes of Health","keywords":"Biology; Single-nucleotide polymorphism; Genetics; Genetic variation; Phenotype; Quantitative trait locus; Genome-wide association study; Genotype; Locus (genetics); Genetic association; Genetic variability; Trait; SNP; Genetic architecture; Evolutionary biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0008783267,0.0003797583,0.001213343,0.00006002869,0.00005720487,0.000006868465,0.0003606729,0.005785523,0.0001025744],"category_scores_gemma":[0.0006140109,0.0002810416,0.0003328415,0.0002462795,0.00008491374,0.000002019457,0.0001076284,0.001515461,0.00001211177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007325958,"about_ca_system_score_gemma":0.0003562793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009766341,"about_ca_topic_score_gemma":0.00001469675,"domain_scores_codex":[0.9979358,0.0004747358,0.000500886,0.0005001508,0.0001852193,0.0004032518],"domain_scores_gemma":[0.9981418,0.0001195288,0.0007080148,0.0006707468,0.0002644304,0.00009547918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002479199,0.001499297,0.1453615,0.01479616,0.01329432,0.00001161779,0.0001577294,0.00003104208,0.0008485243,0.001122704,0.0485707,0.7740585],"study_design_scores_gemma":[0.0002241986,0.0001262222,0.007149726,0.0003569293,0.0009141827,0.000006130002,0.000003968125,0.000003794163,0.00001837343,0.0001626731,0.9906666,0.0003672364],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007834069,0.9964866,0.0003463811,0.00003508505,0.0002652355,0.0004306131,0.0003115796,0.00001144399,0.001329629],"genre_scores_gemma":[0.04301603,0.9524488,0.0008421631,0.0002795339,0.0004215213,0.00005131853,0.001645789,0.00006983091,0.001224971],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9420959,"threshold_uncertainty_score":0.9999642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01518852313628676,"score_gpt":0.2959499182822947,"score_spread":0.2807613951460079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}