{"id":"W2104389902","doi":"10.1074/jbc.m108662200","title":"Purification, Cloning, and Characterization of Nek8, a Novel NIMA-related Kinase, and Its Candidate Substrate Bicd2","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research & Development Corporation","funders":"Fred Hutchinson Cancer Research Center","keywords":"Biology; Cell biology; Casein kinase 2; SH3 domain; Autophosphorylation; Biochemistry; Cyclin-dependent kinase 2; Protein kinase A; Kinase; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001170027,0.0003251,0.0003120019,0.0002694278,0.0002538476,0.0003466559,0.0002949765,0.0002518237,0.0009704905],"category_scores_gemma":[0.000205601,0.0001588943,0.0002271079,0.0002410123,0.0001111558,0.0002069532,0.0002924616,0.000374342,0.001124818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003256851,"about_ca_system_score_gemma":0.0002051393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005580322,"about_ca_topic_score_gemma":0.001018825,"domain_scores_codex":[0.99989,0.00001255487,0.00001352466,0.00003401311,0.00003268508,0.00001729256],"domain_scores_gemma":[0.9999197,0.000008883257,0.00001113983,0.00001120744,0.00001777479,0.0000314087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000966232,0.00001676768,0.001211075,0.00006949897,0.00001009825,0.0001823378,0.00002106985,0.00009700063,0.9939494,0.0001093201,0.000153382,0.00408356],"study_design_scores_gemma":[0.00004596978,0.0001540716,0.02735387,0.00002153956,0.00004005718,0.005454384,0.0001014615,0.005244502,0.9150436,0.0002739205,0.04624501,0.00002166494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975902,0.006007327,0.01195655,0.0004495819,0.00007392871,0.00009113172,0.0024031,0.0001190028,0.002997433],"genre_scores_gemma":[0.9318123,0.003119164,0.0307154,0.0001562809,0.0000437285,0.0001255525,0.02347768,0.00006190701,0.01048789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009704905,"threshold_uncertainty_score":0.003246605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02251905649032563,"score_gpt":0.2273696229707973,"score_spread":0.2048505664804717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}