{"id":"W2104389902","doi":"10.1074/jbc.m108662200","title":"Purification, Cloning, and Characterization of Nek8, a Novel NIMA-related Kinase, and Its Candidate Substrate Bicd2","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research & Development Corporation","funders":"Fred Hutchinson Cancer Research Center","keywords":"Biology; Cell biology; Casein kinase 2; SH3 domain; Autophosphorylation; Biochemistry; Cyclin-dependent kinase 2; Protein kinase A; Kinase; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001883388,0.0001202164,0.0001899447,0.0000190905,0.00004327797,0.00001611874,0.0001033233,0.000234628,0.00007818345],"category_scores_gemma":[0.0001184706,0.00009191869,0.00005268603,0.00006751598,0.00009451671,0.000007481819,0.0000432483,0.0001377733,7.664318e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005568275,"about_ca_system_score_gemma":0.00001705817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.706527e-7,"about_ca_topic_score_gemma":1.242808e-7,"domain_scores_codex":[0.9992413,0.00002425876,0.0003775073,0.0001501848,0.00007734493,0.0001294064],"domain_scores_gemma":[0.999235,0.00001064056,0.0004098911,0.00008997496,0.0001490838,0.0001054186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005314665,0.0000683723,0.002307594,0.00003808728,0.00003310328,0.000003240299,0.00004235098,6.323068e-7,0.9964944,0.00001501839,0.00002718653,0.0009169175],"study_design_scores_gemma":[0.0005707707,0.0002211477,0.0132606,0.00003056091,0.0000157997,0.0002141,0.00002229071,0.00004982513,0.9829774,0.00002468024,0.002502589,0.0001101953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971883,0.002170851,0.00006960948,0.0001911179,0.0000281185,0.00006149523,0.00004247472,0.00000389041,0.0002441112],"genre_scores_gemma":[0.9972805,0.002182281,0.0001406105,0.00005470589,0.0001052107,0.000002515638,0.0000532284,0.000006868768,0.0001741049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01351691,"threshold_uncertainty_score":0.3748335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02251905649032563,"score_gpt":0.2273696229707973,"score_spread":0.2048505664804717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}