{"id":"W2104396164","doi":"10.1124/jpet.110.166629","title":"Reduction of l-DOPA-Induced Dyskinesia by the Selective Metabotropic Glutamate Receptor 5 Antagonist 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Lesioned Macaque Model of Parkinson's Disease","year":2010,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":137,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"","keywords":"Metabotropic glutamate receptor 5; Pharmacology; Chemistry; Metabotropic glutamate receptor; Antagonist; Metabotropic receptor; Glutamate receptor; Metabotropic glutamate receptor 1; Metabotropic glutamate receptor 4; Receptor antagonist; Metabotropic glutamate receptor 2; Stereochemistry; Medicinal chemistry; Receptor; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002003047,0.0005993507,0.0006248722,0.000370501,0.000281739,0.0003982972,0.0004531421,0.0006242983,0.001541792],"category_scores_gemma":[0.0002928796,0.0002954173,0.000306258,0.0001823727,0.0003803721,0.000403885,0.0001609221,0.001112845,0.0004048281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005884183,"about_ca_system_score_gemma":0.0006549965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004531952,"about_ca_topic_score_gemma":0.01277457,"domain_scores_codex":[0.9998085,0.00003756109,0.00002034448,0.00002282062,0.00004319876,0.00006763131],"domain_scores_gemma":[0.9997883,0.00002482949,0.00004914964,0.00002047916,0.00002580081,0.00009148064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001658974,0.000289533,0.0001786441,0.00006361415,0.00002590798,0.0001448743,0.00006374606,0.0001103508,0.9948638,0.0001649516,0.0001723681,0.002263358],"study_design_scores_gemma":[0.000543707,0.0067922,0.008186718,0.00002619468,0.0001023125,0.0004639004,0.0001380437,0.003452551,0.9781582,0.0001215064,0.001988705,0.00002614876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977098,0.0006697653,0.0003049293,0.0001425932,0.00003827014,0.0000242095,0.0002310914,0.00007133219,0.000807976],"genre_scores_gemma":[0.9958805,0.0005618134,0.000492832,0.00005005094,0.00001740143,0.00004347241,0.00039185,0.00002120643,0.002540816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004531952,"threshold_uncertainty_score":0.009011149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04583114982912571,"score_gpt":0.3607947346796809,"score_spread":0.3149635848505552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}