{"id":"W2104396164","doi":"10.1124/jpet.110.166629","title":"Reduction of l-DOPA-Induced Dyskinesia by the Selective Metabotropic Glutamate Receptor 5 Antagonist 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Lesioned Macaque Model of Parkinson's Disease","year":2010,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":137,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"","keywords":"Metabotropic glutamate receptor 5; Pharmacology; Chemistry; Metabotropic glutamate receptor; Antagonist; Metabotropic receptor; Glutamate receptor; Metabotropic glutamate receptor 1; Metabotropic glutamate receptor 4; Receptor antagonist; Metabotropic glutamate receptor 2; Stereochemistry; Medicinal chemistry; Receptor; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001006048,0.0003167402,0.0005092543,0.0002286657,0.0004020581,0.00004013345,0.0009683833,0.0001280331,0.0000656049],"category_scores_gemma":[0.00009685422,0.0001978923,0.0001826213,0.0007454318,0.001338159,0.0003806498,0.0001320951,0.001496265,0.000001927285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005019144,"about_ca_system_score_gemma":0.0002743276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008483614,"about_ca_topic_score_gemma":7.019925e-7,"domain_scores_codex":[0.9963604,0.001304448,0.0007830361,0.0004308228,0.0006442606,0.0004770235],"domain_scores_gemma":[0.9980978,0.0006253629,0.0007327695,0.0002338211,0.0001529633,0.0001572566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002879343,0.001156615,0.0002238562,0.00002079726,0.00004673856,0.00004859417,0.0009713464,0.0001909214,0.9934717,0.000131588,0.0005137275,0.0003447966],"study_design_scores_gemma":[0.0022387,0.0009325185,0.0002234505,0.000009177389,0.0001417845,0.000249444,0.0003342379,0.005172396,0.9894673,0.0001956847,0.0008655583,0.0001697747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925242,0.0007127607,0.00001723785,0.004591702,0.001522291,0.0005524008,0.00003881742,0.00001105579,0.00002951834],"genre_scores_gemma":[0.9954603,0.002160202,0.00007101815,0.002005671,0.0002015992,0.00003380509,7.855036e-7,0.00003054159,0.00003610317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004981474,"threshold_uncertainty_score":0.8069812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04583114982912571,"score_gpt":0.3607947346796809,"score_spread":0.3149635848505552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}