{"id":"W2104401957","doi":"10.1097/mib.0b013e3182a85709","title":"Increased Prevalence of Circulating Novel IL-17 Secreting Foxp3 Expressing CD4+ T Cells and Defective Suppressive Function of Circulating Foxp3+ Regulatory Cells Support Plasticity Between Th17 and Regulatory T Cells in Inflammatory Bowel Disease Patients","year":2013,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":203,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"FOXP3; Immunology; Medicine; Immune system; Inflammatory bowel disease; Peripheral blood mononuclear cell; Population; Regulatory T cell; T cell; RAR-related orphan receptor gamma; IL-2 receptor; Biology; Internal medicine; In vitro; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004045131,0.0007142802,0.0008321697,0.0004375765,0.00039972,0.00006237037,0.0002587015,0.0004482758,0.0001619875],"category_scores_gemma":[0.0003033968,0.0007379764,0.0002693978,0.0001620124,0.0008334286,0.0008892772,0.0003581436,0.0003257871,0.00001405267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001517679,"about_ca_system_score_gemma":0.0003034426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000103032,"about_ca_topic_score_gemma":0.000008014475,"domain_scores_codex":[0.9958429,0.0006419922,0.00141777,0.001025854,0.000310078,0.000761447],"domain_scores_gemma":[0.9961454,0.001179671,0.001407134,0.0005953116,0.0003545573,0.0003179076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003756457,0.0002325257,0.6248888,0.001466396,0.0002533892,0.00002049936,0.0006871891,0.0003209386,0.370743,0.00001783655,0.00006557565,0.0009282655],"study_design_scores_gemma":[0.003461748,0.000135157,0.9030275,0.001027263,0.000839647,0.000003098052,0.0003721327,0.0001941569,0.09019213,0.0001280861,0.00001351269,0.0006055435],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952151,0.001201618,0.00006592843,0.00000365724,0.0003262004,0.001436999,0.001586557,0.0001035565,0.00006042683],"genre_scores_gemma":[0.9992108,0.00004691207,0.00008938971,0.00002498724,0.00009242135,0.0001658368,0.0002307154,0.00008190033,0.00005706538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2805508,"threshold_uncertainty_score":0.9995071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008650069151674737,"score_gpt":0.2000463306102978,"score_spread":0.1913962614586231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}