{"id":"W2104401957","doi":"10.1097/mib.0b013e3182a85709","title":"Increased Prevalence of Circulating Novel IL-17 Secreting Foxp3 Expressing CD4+ T Cells and Defective Suppressive Function of Circulating Foxp3+ Regulatory Cells Support Plasticity Between Th17 and Regulatory T Cells in Inflammatory Bowel Disease Patients","year":2013,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":203,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"FOXP3; Immunology; Medicine; Immune system; Inflammatory bowel disease; Peripheral blood mononuclear cell; Population; Regulatory T cell; T cell; RAR-related orphan receptor gamma; IL-2 receptor; Biology; Internal medicine; In vitro; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001629022,0.0002232205,0.0003055006,0.0004547032,0.000174524,0.0003115521,0.0001310352,0.000288984,0.002125263],"category_scores_gemma":[0.0005797932,0.0001162949,0.0001507562,0.0002418606,0.0001563749,0.0001668663,0.0001424074,0.0003131784,0.0001745335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001031863,"about_ca_system_score_gemma":0.00008807376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002419965,"about_ca_topic_score_gemma":0.0002407503,"domain_scores_codex":[0.9998896,0.00002216122,0.00001384794,0.00003161053,0.00002013976,0.00002268927],"domain_scores_gemma":[0.9996545,0.00008636861,0.0001461928,0.00002052101,0.00003281038,0.00005959897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002267543,0.0001624819,0.8646287,0.0001434677,0.00008206438,0.001882958,0.0002596382,0.0001253287,0.1130537,0.00005546535,0.0002072224,0.01713143],"study_design_scores_gemma":[0.00008849112,0.0009074713,0.9776225,0.00003172815,0.0001280626,0.01004977,0.0002870414,0.0003764933,0.009522366,0.0001035027,0.0008743949,0.000008133031],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992871,0.0003987429,0.0001211152,0.00001047053,0.000003180877,0.000003622425,0.00004012518,0.000004660774,0.0001309429],"genre_scores_gemma":[0.9995015,0.0001098908,0.0001642743,0.00001332165,0.00001564056,0.000006288305,0.00009526354,0.000001846811,0.00009210823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002125263,"threshold_uncertainty_score":0.007109702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008650069151674737,"score_gpt":0.2000463306102978,"score_spread":0.1913962614586231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}