{"id":"W2104403020","doi":"10.1128/jvi.00620-09","title":"The Transmembrane Domain of BST-2 Determines Its Sensitivity to Down-Modulation by Human Immunodeficiency Virus Type 1 Vpu","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institutes of Health; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Tetherin; Transmembrane protein; Transmembrane domain; Biology; Virology; Cell biology; Viral replication; Virus; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006717806,0.0001181481,0.0003113692,0.0001136957,0.0002198926,0.000008366132,0.0001718331,0.0001434222,0.00008518817],"category_scores_gemma":[0.0000899817,0.00007440255,0.0001084676,0.0001247649,0.0001385917,0.00006649885,0.00001798994,0.000257847,0.00009950261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003404445,"about_ca_system_score_gemma":0.00004956107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002650838,"about_ca_topic_score_gemma":0.00004698258,"domain_scores_codex":[0.9986379,0.0004355701,0.0004319513,0.0001171831,0.00006927286,0.0003081817],"domain_scores_gemma":[0.9991735,0.0002206464,0.0002250722,0.0001671654,0.0001777923,0.00003585774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008825984,0.0002620683,0.000251576,0.000003205507,0.00009798259,0.00003502524,0.0002489911,0.00003478987,0.9835759,0.0001385855,0.0008308545,0.0136384],"study_design_scores_gemma":[0.004572168,0.01249485,0.1725933,0.00003810347,0.0001050129,0.001350947,0.0001200193,0.00001299307,0.7726843,0.001100277,0.03468314,0.0002449723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938834,0.003494803,0.0002291607,0.001783703,0.0002045923,0.0001426431,0.00002914015,0.000005844779,0.0002266744],"genre_scores_gemma":[0.9992793,0.0002708386,0.00004229834,0.0001317612,0.00002546095,0.000001255768,0.0000145061,0.000005508681,0.0002290413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2108916,"threshold_uncertainty_score":0.3034048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01207145912323715,"score_gpt":0.2858371344186316,"score_spread":0.2737656752953945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}