{"id":"W2104415321","doi":"10.1038/nature10238","title":"The crystal structure of a voltage-gated sodium channel","year":2011,"lang":"en","type":"article","venue":"Nature","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1438,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Howard Hughes Medical Institute","keywords":"Gating; Chemistry; Potassium channel; Ion channel; Selectivity; Biophysics; Voltage-gated ion channel; Sodium channel; Crystallography; Sodium; Receptor; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002548885,0.0002313344,0.0004854086,0.0001084996,0.0005814964,0.0009471136,0.0005122447,0.0005692385,0.001250673],"category_scores_gemma":[0.0005445243,0.0002135114,0.0001686281,0.0003547786,0.0004101408,0.0006445798,0.0002406555,0.001473085,0.0003685503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009551407,"about_ca_system_score_gemma":0.001706908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003822531,"about_ca_topic_score_gemma":0.004928903,"domain_scores_codex":[0.9999086,0.000008088008,0.000004859536,0.00001394089,0.00004890199,0.00001569397],"domain_scores_gemma":[0.999873,0.00002681366,0.00001751914,0.000007472575,0.00003340917,0.00004171924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001897122,0.000677249,0.007368245,0.001265264,0.0001710687,0.003018168,0.0007336342,0.02714041,0.6658741,0.05272171,0.1088057,0.1303273],"study_design_scores_gemma":[0.001434972,0.001072368,0.02924003,0.0002548354,0.0002749291,0.00398274,0.001253271,0.1739111,0.418021,0.0359862,0.3343178,0.0002506435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9362487,0.01037503,0.01604513,0.009941983,0.002143465,0.00009787818,0.003329782,0.0007936973,0.02102432],"genre_scores_gemma":[0.9466284,0.01048659,0.01558644,0.001257201,0.0002301484,0.00008447853,0.008416219,0.00009957022,0.01721102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003822531,"threshold_uncertainty_score":0.007600546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008418903916892222,"score_gpt":0.2213846474094171,"score_spread":0.2129657434925249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}