{"id":"W2104441503","doi":"10.1182/blood.v98.4.1003","title":"Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase","year":2001,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Hospital for Sick Children","funders":"National Cancer Institute; Cancer Research Society","keywords":"SOD1; Biology; Superoxide dismutase; Fanconi anemia; Haematopoiesis; Progenitor cell; Bone marrow; SOD2; Molecular biology; Myeloid; Immunology; Cancer research; Oxidative stress; Stem cell; Cell biology; Endocrinology; DNA repair; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":{"n_in":0,"stratum":"aff_core","weight":5595.2375,"opus":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Mouse genetics of hematopoiesis in Fanconi anemia models."},"gpt":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"The study examines gene deficiencies and disease phenotypes in mice."},"grok":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Mouse genetics of Fanconi anemia and superoxide dismutase; biomedical disease model."}},"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001952494,0.001389533,0.0003822467,0.001671383,0.0002681937,0.0004671877,0.0002865051,0.0007197353,0.001705959],"category_scores_gemma":[0.0001851747,0.0005812182,0.0003233215,0.0003886301,0.0007424788,0.0003067103,0.0005155202,0.000907161,0.0005107175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003060236,"about_ca_system_score_gemma":0.0002231303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005173642,"about_ca_topic_score_gemma":0.0008878583,"domain_scores_codex":[0.9997193,0.00003983083,0.00003655884,0.0000794623,0.00007444473,0.000050324],"domain_scores_gemma":[0.999453,0.00003857182,0.0002393074,0.00004453779,0.00002340182,0.0002011781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000533066,0.00008791354,0.001189311,0.0000343046,0.00002073556,0.0004813106,0.00004268263,0.0001249198,0.9956232,0.0003236159,0.00006766598,0.001471343],"study_design_scores_gemma":[0.0003917454,0.002116488,0.06503502,0.00006230945,0.0001844239,0.01159738,0.0001788059,0.003100246,0.912286,0.001031465,0.003966239,0.00004978841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929885,0.001164271,0.003022639,0.0001215261,0.00001926821,0.00003642074,0.0007862091,0.0004137724,0.001447376],"genre_scores_gemma":[0.9912364,0.0008938721,0.003037576,0.00008658687,0.0000196315,0.00006910296,0.001015328,0.0001079447,0.003533443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001705959,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007063531847221747,"score_gpt":0.2061238987260164,"score_spread":0.1990603668787947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}