{"id":"W2104462112","doi":"10.1128/mcb.02025-05","title":"Critical Role for a Single Leucine Residue in Leukemia Induction by E2A-PBX1","year":2006,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Queen's University","keywords":"Biology; Transcription factor; Coactivator; Cell biology; DNA-binding protein; Fusion protein; Molecular biology; Homeobox; Genetics; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001396165,0.0002423546,0.0002056922,0.0001153319,0.000283674,0.0002396611,0.0001656194,0.0002587884,0.00203075],"category_scores_gemma":[0.0001763714,0.0001017121,0.0001411304,0.0000590698,0.0002534344,0.0001525196,0.0003122607,0.0002405518,0.001071331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003126066,"about_ca_system_score_gemma":0.0002246227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003178119,"about_ca_topic_score_gemma":0.0003821751,"domain_scores_codex":[0.9998828,0.00003128587,0.00001499035,0.00002722177,0.00002216094,0.000021519],"domain_scores_gemma":[0.9997813,0.00004404248,0.00005745521,0.00001603223,0.00001749019,0.000083636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002615679,0.00002760944,0.0005138469,0.00002244567,0.000001843022,0.0001447713,0.00001162376,0.00006164087,0.9979039,0.00009969639,0.00001959181,0.0009313939],"study_design_scores_gemma":[0.00004373926,0.0004255478,0.01108285,0.00000944527,0.000009026261,0.001455907,0.000037863,0.001202294,0.9826987,0.000104417,0.002920874,0.000009407871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968899,0.0007052485,0.001273788,0.00007963876,0.00001338206,0.00001310036,0.00008721727,0.00006702766,0.0008705875],"genre_scores_gemma":[0.998054,0.0001266707,0.0009260547,0.00003387676,0.000006225511,0.000009519787,0.0001546356,0.00001246376,0.000676586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00203075,"threshold_uncertainty_score":0.006793559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003844283135310029,"score_gpt":0.2106844442786014,"score_spread":0.2068401611432914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}