{"id":"W2104462112","doi":"10.1128/mcb.02025-05","title":"Critical Role for a Single Leucine Residue in Leukemia Induction by E2A-PBX1","year":2006,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Queen's University","keywords":"Biology; Transcription factor; Coactivator; Cell biology; DNA-binding protein; Fusion protein; Molecular biology; Homeobox; Genetics; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001492614,0.0001751498,0.0001853814,0.00005299629,0.00006395384,0.00002423797,0.0001086936,0.0003239158,0.00000519926],"category_scores_gemma":[0.00005537384,0.0001817148,0.00007091172,0.00006139961,0.0001265557,0.000003002057,0.00007503777,0.00008946117,0.000001630839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003487844,"about_ca_system_score_gemma":0.00004254074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001956417,"about_ca_topic_score_gemma":0.00007161934,"domain_scores_codex":[0.9988685,0.00006571352,0.0002511274,0.000444268,0.00004317688,0.0003272441],"domain_scores_gemma":[0.9996129,0.00001407598,0.00004781628,0.0002198116,0.00005147037,0.00005395046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004660157,0.00007108207,0.0006430412,0.00001889264,0.00001221135,0.000005125411,0.000008164136,0.00007185543,0.9953021,0.002524315,0.0004334177,0.0008631513],"study_design_scores_gemma":[0.0008505354,0.0005208786,0.0001938815,0.000007045297,0.00002001313,0.0000307297,0.00004644268,0.0006481819,0.9745042,0.006251873,0.01665969,0.0002665662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683623,0.004172942,0.02599683,0.0002416973,0.00009361231,0.0002008622,0.00005011271,0.000009593135,0.0008720134],"genre_scores_gemma":[0.9967878,0.0000365758,0.001557367,0.000218719,0.0001213824,0.0000433947,0.001029982,0.00002908136,0.0001757399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02842542,"threshold_uncertainty_score":0.7410116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003844283135310029,"score_gpt":0.2106844442786014,"score_spread":0.2068401611432914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}