{"id":"W2104475657","doi":"10.1016/j.molimm.2012.10.044","title":"Monitoring and modeling treatment of atypical hemolytic uremic syndrome","year":2012,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Akershus Universitetssykehus; Heart and Stroke Foundation of Canada","keywords":"Atypical hemolytic uremic syndrome; Eculizumab; Properdin; Complement system; Alternative complement pathway; Factor H; Complement component 5; Immunology; Medicine; Complement factor B; Thrombotic microangiopathy; Complement factor I; Antibody; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003418595,0.0002530198,0.0002740097,0.0001521971,0.0001061524,0.0004562339,0.0003245184,0.0003115664,0.0002124814],"category_scores_gemma":[0.0007406069,0.00006168518,0.000147695,0.00009790352,0.0001330079,0.0002356693,0.000144211,0.000316701,0.00004369852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002969412,"about_ca_system_score_gemma":0.0003847785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007043879,"about_ca_topic_score_gemma":0.0005200412,"domain_scores_codex":[0.9998444,0.00008316198,0.000009236237,0.00001803029,0.00003168159,0.00001348373],"domain_scores_gemma":[0.9998661,0.0000488863,0.00004883667,0.0000118624,0.00001032868,0.00001390782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00851228,0.002648182,0.1295346,0.0005030495,0.0003211488,0.002672518,0.0002420987,0.2448332,0.262216,0.009993296,0.00286018,0.3356635],"study_design_scores_gemma":[0.0002892764,0.006494337,0.03410766,0.00009656078,0.0003538617,0.003183303,0.0001363092,0.8013489,0.1420387,0.005485679,0.006416849,0.0000485708],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9566481,0.003305151,0.03754911,0.0005586433,0.00006073973,0.00007875462,0.00008105211,0.0001448561,0.001573606],"genre_scores_gemma":[0.9957787,0.0006054395,0.003446573,0.00002511003,0.00001220881,0.00001761442,0.00002346856,0.000002131023,0.00008877498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007043879,"threshold_uncertainty_score":0.00215441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02692980167201262,"score_gpt":0.2724581478429884,"score_spread":0.2455283461709758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}