{"id":"W2104475657","doi":"10.1016/j.molimm.2012.10.044","title":"Monitoring and modeling treatment of atypical hemolytic uremic syndrome","year":2012,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Akershus Universitetssykehus; Heart and Stroke Foundation of Canada","keywords":"Atypical hemolytic uremic syndrome; Eculizumab; Properdin; Complement system; Alternative complement pathway; Factor H; Complement component 5; Immunology; Medicine; Complement factor B; Thrombotic microangiopathy; Complement factor I; Antibody; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000076461,0.000180848,0.0003622264,0.0001111732,0.00007212978,0.000004048677,0.0001213826,0.0001651309,0.0001174745],"category_scores_gemma":[0.00002380479,0.0001673099,0.00009275087,0.00006669272,0.0001366943,0.00005283316,0.00007179427,0.00007953825,0.00008468283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007631574,"about_ca_system_score_gemma":0.00002026987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007615401,"about_ca_topic_score_gemma":7.104679e-7,"domain_scores_codex":[0.9988578,0.0001724634,0.0003066153,0.000203867,0.00002890928,0.000430356],"domain_scores_gemma":[0.999465,0.00006079359,0.00007876415,0.000335804,0.00003150342,0.0000281332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001499747,0.0003246753,0.0582898,0.00002522354,0.0005669344,0.00001865883,0.0004079267,0.00003493724,0.9374415,0.0006328246,0.00000867324,0.002098899],"study_design_scores_gemma":[0.005594274,0.00165622,0.127911,0.0002380758,0.0005479537,0.003079494,0.0009220125,0.0001406809,0.8565431,0.0004431521,0.002222898,0.0007011371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9288152,0.06967741,0.0005510493,0.00004366043,0.0005713713,0.0002302333,0.00000858802,0.00004495849,0.00005755795],"genre_scores_gemma":[0.9994674,0.0002219698,0.0001384868,0.000008497275,0.0000147668,0.00004537761,0.00002284627,0.00001912048,0.00006156199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08089834,"threshold_uncertainty_score":0.6822698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02692980167201262,"score_gpt":0.2724581478429884,"score_spread":0.2455283461709758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}