{"id":"W2104493082","doi":"10.1039/c4tb00477a","title":"Anionic fibroin-derived polypeptides accelerate MSC osteoblastic differentiation in a three-dimensional osteoid-like dense collagen niche","year":2014,"lang":"en","type":"article","venue":"Journal of Materials Chemistry B","topic":"Bone Tissue Engineering Materials","field":"Engineering","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Fibroin; Osteoid; Mesenchymal stem cell; Cell biology; Matrix (chemical analysis); Niche; Extracellular matrix; Materials science; Chemistry; Biophysics; Anatomy; Biochemistry; Biology; Composite material; SILK","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002105564,0.0003205595,0.0001135436,0.0001883963,0.0001036302,0.0002977426,0.00008345838,0.0002282038,0.0007585832],"category_scores_gemma":[0.0001349376,0.0001253908,0.0001251137,0.0001140659,0.0001889395,0.0002070136,0.0001655097,0.0003169577,0.0002021786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001573669,"about_ca_system_score_gemma":0.0002241837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004681841,"about_ca_topic_score_gemma":0.001218756,"domain_scores_codex":[0.9998913,0.00001660789,0.000009413549,0.0000159277,0.00003986052,0.00002697036],"domain_scores_gemma":[0.999799,0.00004810849,0.00004943424,0.00001387024,0.00002149447,0.00006814902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002667689,0.00000818805,0.00002763072,0.000007979288,6.373288e-7,0.00001518979,0.000008020564,0.00003243546,0.9993304,0.00004236983,0.000006442111,0.0004941847],"study_design_scores_gemma":[0.000007425449,0.0001044779,0.0009496216,0.000002535409,0.000003745376,0.00008509678,0.00001134827,0.000442247,0.9972315,0.00001909303,0.001140346,0.000002555523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918908,0.0004620783,0.006014111,0.00003860951,0.00002261819,0.00002418323,0.00006358381,0.00007882005,0.001405231],"genre_scores_gemma":[0.992465,0.0004031149,0.004265657,0.00002281659,0.000008749434,0.00001569735,0.00007564371,0.00002724205,0.002716108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007585832,"threshold_uncertainty_score":0.002537727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008007116312272739,"score_gpt":0.194997200055068,"score_spread":0.1869900837427953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}