{"id":"W2104503053","doi":"10.1038/onc.2010.612","title":"Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma","year":2011,"lang":"en","type":"article","venue":"Oncogene","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":274,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Centre Hospitalier Universitaire de Nice; Institut National Du Cancer; Ligue Contre le Cancer; Agence Nationale de la Recherche","keywords":"Microphthalmia-associated transcription factor; Biology; Genetics; Transcription factor; Mitosis; Melanoma; Chromatin immunoprecipitation; Licensing factor; Cancer research; Cell biology; DNA replication; Gene; Control of chromosome duplication; Gene expression; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009445491,0.00006322437,0.00008526078,0.0000222331,0.00001833002,0.000003229256,0.00005589248,0.00007497781,0.00003699925],"category_scores_gemma":[0.000014313,0.00006510978,0.00003718192,0.00002558666,0.00002888003,0.000002837791,0.00001213019,0.00001562077,5.929336e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000107393,"about_ca_system_score_gemma":0.00002198723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000504372,"about_ca_topic_score_gemma":0.00005942658,"domain_scores_codex":[0.9994534,0.00002852423,0.0001739403,0.0002300199,0.00003413815,0.00007994987],"domain_scores_gemma":[0.999672,0.000004318111,0.00006067757,0.0001988405,0.00003781862,0.00002633466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001586983,0.00006276699,0.02356027,0.00002183258,0.00001376368,1.03178e-7,0.0004225084,1.738299e-7,0.9726361,0.00001900244,0.000008001495,0.003096752],"study_design_scores_gemma":[0.0004465711,0.0001578743,0.07693987,0.000002857364,0.00001074994,0.000002950273,0.0001004281,0.000012673,0.9217261,0.0001068632,0.0004307746,0.00006228251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983264,0.0004399232,0.0006257652,0.00001023226,0.00004417658,0.0002443258,0.0000826443,0.000002316513,0.0002241677],"genre_scores_gemma":[0.9977418,0.00008266512,0.001943371,0.00001064746,0.0000425766,0.00003331776,0.0001078236,0.000008392544,0.00002947391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0533796,"threshold_uncertainty_score":0.26551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02258012537723678,"score_gpt":0.2528859474998503,"score_spread":0.2303058221226135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}