{"id":"W2104531065","doi":"10.1101/gad.935901","title":"Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain","year":2001,"lang":"en","type":"article","venue":"Genes & Development","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":421,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institutes of Health; National Institute of General Medical Sciences; Seoul National University; Leukemia and Lymphoma Society","keywords":"RNA polymerase II; Biology; Transcription factor II D; RNA polymerase II holoenzyme; Transcription factor II E; Transcription factor II F; Molecular biology; Transcription factor II B; Transcription (linguistics); Transcription factor II H; Phosphorylation; General transcription factor; RNA polymerase; Cell biology; Promoter; RNA; Biochemistry; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009581322,0.0001375314,0.0001381495,0.0000204326,0.0001448131,0.000006289948,0.0001491461,0.00007075074,0.000008361154],"category_scores_gemma":[0.000008802343,0.000108957,0.0000483814,0.0000540919,0.00007520201,0.000001865401,0.0004232232,0.00002915139,7.708953e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002294514,"about_ca_system_score_gemma":0.00009851138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001379696,"about_ca_topic_score_gemma":0.00003412509,"domain_scores_codex":[0.9992499,0.00002782912,0.0002342799,0.0002020969,0.0001094206,0.0001764486],"domain_scores_gemma":[0.9995178,0.000008020009,0.000129895,0.0002502701,0.00003351196,0.00006051135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005786991,0.00006832102,0.006818722,0.0000947459,0.0000540093,0.00001290651,0.0002810979,0.00002254299,0.970275,0.00002742151,0.00009252099,0.02219485],"study_design_scores_gemma":[0.0005444052,0.00007731032,0.01762955,0.00004593467,0.00001808592,0.00004799901,0.00003845982,0.00002487315,0.9736557,0.00002647115,0.007752929,0.0001383049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940718,0.005338166,0.0001479251,0.00004852823,0.0001259123,0.0001665625,0.00001318763,0.000002350418,0.00008557185],"genre_scores_gemma":[0.9956156,0.0004744802,0.003356556,0.0001058122,0.00002785166,0.00001158207,0.00005078575,0.00001400997,0.0003433296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02205655,"threshold_uncertainty_score":0.4443138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003451949376164284,"score_gpt":0.1959647229403865,"score_spread":0.1925127735642222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}