{"id":"W2104546788","doi":"10.1074/jbc.m401395200","title":"The Structural Basis for Methylmalonic Aciduria","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Methionine Adenosyltransferase; Cobalamin; Biology; Thermoplasma acidophilum; Enzyme kinetics; Biochemistry; Complementation; Chemistry; Active site; Stereochemistry; Mutant; Enzyme; Gene; Amino acid; Methionine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008524809,0.0003230716,0.0002383814,0.0003203933,0.0002305375,0.0002368897,0.0004353379,0.000566415,0.001015116],"category_scores_gemma":[0.0002623424,0.0001297312,0.0002685015,0.0002117864,0.0003343219,0.0001035935,0.0003231865,0.0004505582,0.0003433037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000384811,"about_ca_system_score_gemma":0.0002753838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00075452,"about_ca_topic_score_gemma":0.0003401526,"domain_scores_codex":[0.9999073,0.00001404996,0.0000102323,0.00002455805,0.00003057733,0.00001326572],"domain_scores_gemma":[0.9998958,0.00001103909,0.00004066627,0.000007786693,0.00001448327,0.00003014896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004597557,0.00005303692,0.006077507,0.0001332219,0.00006112511,0.006053161,0.00009661482,0.0004678486,0.9726633,0.001933019,0.0003715635,0.01162996],"study_design_scores_gemma":[0.0002860076,0.0007823588,0.1321321,0.0000995899,0.0002688569,0.04498144,0.0002146388,0.009258081,0.7728907,0.004433261,0.03458337,0.00006962576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903594,0.003106941,0.00392045,0.0004979098,0.0001249293,0.00002372328,0.0002831886,0.0002321265,0.001451271],"genre_scores_gemma":[0.9974775,0.000498259,0.00117426,0.00006719449,0.00002285726,0.000007916023,0.000272347,0.00001021572,0.0004694546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001015116,"threshold_uncertainty_score":0.003395915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318518432419586,"score_gpt":0.2665181983923118,"score_spread":0.253333014068116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}