{"id":"W2104551057","doi":"10.1124/mol.64.1.170","title":"Generation and Functional Characterization of Arylamine N-Acetyltransferase Nat1/Nat2Double-Knockout Mice","year":2003,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"Acetyltransferases; Knockout mouse; Arylamine N-acetyltransferase; Molecular biology; Biology; In vivo; Isozyme; Carcinogen; Spleen; Enzyme; Phenotype; Chemistry; Biochemistry; Acetylation; Gene; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009594155,0.001553698,0.0009291224,0.002347142,0.0007202688,0.000921137,0.001228295,0.001282903,0.005491743],"category_scores_gemma":[0.0006243759,0.0009502075,0.0009813453,0.0005095724,0.00104689,0.0009222039,0.0006831872,0.002672772,0.001910781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005778788,"about_ca_system_score_gemma":0.0003460312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007408377,"about_ca_topic_score_gemma":0.001428191,"domain_scores_codex":[0.9991477,0.00008681629,0.0001733441,0.0002373178,0.0002336652,0.0001212472],"domain_scores_gemma":[0.998623,0.0002562633,0.0004656691,0.0001322626,0.0001490813,0.0003737395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002853482,0.0001001282,0.0002747746,0.00006111577,0.00002942594,0.0003068084,0.00006372955,0.0001262062,0.9959987,0.0007948426,0.0002009959,0.001757874],"study_design_scores_gemma":[0.0002481999,0.0003972898,0.004716028,0.00004568355,0.000168306,0.002419134,0.0001320957,0.001797161,0.9801107,0.0003844841,0.00954145,0.00003945675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9332484,0.001948795,0.04731328,0.001190337,0.0004034634,0.0005921652,0.009605899,0.001254005,0.00444361],"genre_scores_gemma":[0.9084962,0.002921263,0.03837015,0.0005822153,0.0001739297,0.001091017,0.009201913,0.00156805,0.03759526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005491743,"threshold_uncertainty_score":0.0183717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01932640318806935,"score_gpt":0.2603515081823625,"score_spread":0.2410251049942932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}