{"id":"W2104564014","doi":"10.1158/1078-0432.ccr-05-2423","title":"A Phase I Biological and Pharmacologic Study of the Heparanase Inhibitor PI-88 in Patients with Advanced Solid Tumors","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Pharmacokinetics; Medicine; Toxicity; Partial thromboplastin time; Pharmacology; Heparanase; Pharmacodynamics; Internal medicine; Gastroenterology; Coagulation; Cancer; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000746883,0.001238443,0.00127114,0.0003045767,0.0003529349,0.0005477888,0.0004653446,0.0006976444,0.001598373],"category_scores_gemma":[0.0005741877,0.0004015446,0.000655997,0.0003247657,0.0007766792,0.0004814695,0.0002669559,0.002302259,0.0004933192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006580358,"about_ca_system_score_gemma":0.001123177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005418716,"about_ca_topic_score_gemma":0.0008369469,"domain_scores_codex":[0.9996767,0.0001517192,0.00001387587,0.00003956171,0.0000446725,0.00007356643],"domain_scores_gemma":[0.99963,0.00006022135,0.00007295391,0.00003400501,0.00002470225,0.0001782317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3208665,0.1067346,0.04530205,0.001200569,0.001480798,0.00172438,0.0008898575,0.007491879,0.2389737,0.0005996702,0.006194475,0.2685415],"study_design_scores_gemma":[0.1681038,0.7701344,0.03969226,0.00003293369,0.0003112391,0.001304488,0.00009964623,0.002053969,0.01339626,0.0001484991,0.004692169,0.00003026731],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966486,0.001064127,0.0004170172,0.0001965222,0.00003443313,0.0007389085,0.0002336956,0.00003361054,0.0006330553],"genre_scores_gemma":[0.9949747,0.0009278115,0.001125856,0.0002886094,0.00009366535,0.001018585,0.0007098299,0.000010933,0.0008500199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001598373,"threshold_uncertainty_score":0.005347013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07814163126720325,"score_gpt":0.4798012006300278,"score_spread":0.4016595693628245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}