{"id":"W2104568818","doi":"10.1093/hmg/ddr176","title":"Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative","year":2011,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institutes of Health; CHDI Foundation","keywords":"Huntingtin; Biology; Huntington's disease; Huntingtin Protein; Mutant; Molecular biology; Genetically modified mouse; Transgene; Cell biology; Genetics; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001563551,0.0005772169,0.0002639216,0.0003406649,0.0001303981,0.0002656859,0.0003386322,0.0005254544,0.001526598],"category_scores_gemma":[0.0001198709,0.0002308102,0.0002677832,0.0001891786,0.0004617722,0.0002387194,0.0002676591,0.0007691075,0.0007795607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002329397,"about_ca_system_score_gemma":0.0001372543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003381408,"about_ca_topic_score_gemma":0.000767322,"domain_scores_codex":[0.999846,0.00001278148,0.00001941557,0.00004954654,0.0000506288,0.00002154821],"domain_scores_gemma":[0.9997104,0.00002698297,0.000139638,0.00002896356,0.00001583305,0.00007810411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006327004,0.00002554842,0.0001819788,0.00001528608,0.000005706333,0.00008712881,0.00001505333,0.0000218153,0.9988542,0.00005791722,0.00002485159,0.0006473775],"study_design_scores_gemma":[0.0001336215,0.0008609653,0.01317273,0.00002202164,0.00006293385,0.002810193,0.00005249776,0.001074862,0.9770337,0.0002740143,0.004486552,0.00001590965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920149,0.000755556,0.004801722,0.0001415913,0.00003014049,0.00004801244,0.0007590757,0.0003035843,0.00114538],"genre_scores_gemma":[0.9768746,0.001481941,0.008712643,0.0001339125,0.00002602949,0.00008490714,0.002262699,0.00009180755,0.0103314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001526598,"threshold_uncertainty_score":0.005106986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04480614519329146,"score_gpt":0.2531012985794885,"score_spread":0.208295153386197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}