{"id":"W2104585553","doi":"10.1503/jpn.120133","title":"Cytochrome P450–mediated drug metabolism in the brain","year":2013,"lang":"en","type":"review","venue":"Journal of Psychiatry and Neuroscience","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research","keywords":"Drug metabolism; Cytochrome P450; Drug; Pharmacology; Metabolism; CYP2D6; Medicine; Neuroscience; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002833677,0.0006661513,0.001063653,0.001545604,0.0002684355,0.0006846876,0.0006077714,0.0007491434,0.00523791],"category_scores_gemma":[0.0003688211,0.0002137222,0.0004819767,0.002036666,0.0003271499,0.0008495508,0.000466329,0.001078789,0.004177435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004492604,"about_ca_system_score_gemma":0.000775087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001141881,"about_ca_topic_score_gemma":0.00197872,"domain_scores_codex":[0.9998248,0.00002905518,0.00002227883,0.00003523605,0.00007197697,0.00001662398],"domain_scores_gemma":[0.9998453,0.00005277473,0.00002781993,0.000006599329,0.00005247621,0.00001509111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004615558,0.00005317184,0.0003208991,0.009382864,0.0000883333,0.0003492174,0.00003740967,0.0002825927,0.004157369,0.002178191,0.02245148,0.9606523],"study_design_scores_gemma":[0.00001744032,0.00008591653,0.002064804,0.00174251,0.0001071573,0.003528132,0.00004291684,0.000125855,0.001889822,0.002205376,0.9881675,0.00002257676],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003801453,0.994995,0.0004965469,0.0002830416,0.0001359884,0.00001094909,0.00005386907,0.00002609647,0.003618461],"genre_scores_gemma":[0.002085537,0.9953737,0.000376952,0.0001327529,0.0001171067,0.00001095502,0.00007413598,0.000002440556,0.001826559],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00523791,"threshold_uncertainty_score":0.01752257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1317124688735399,"score_gpt":0.4560111337267143,"score_spread":0.3242986648531744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}