{"id":"W2104591429","doi":"10.1038/labinvest.3780279","title":"Increases in Renal ε-(γ-Glutamyl)-Lysine Crosslinks Result from Compartment-Specific Changes in Tissue Transglutaminase in Early Experimental Diabetic Nephropathy: Pathologic Implications","year":2001,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Blood properties and coagulation","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Sheffield Kidney Research Foundation; Trent University; Nottingham Trent University","keywords":"Tissue transglutaminase; Extracellular; Kidney; Extracellular matrix; Diabetic nephropathy; Nephropathy; Glomerulosclerosis; Fibrosis; Internal medicine; Endocrinology; Chemistry; Renal glomerulus; Glomerulonephritis; Proteinuria; Biology; Pathology; Diabetes mellitus; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002779058,0.0002261928,0.0003693282,0.0003154911,0.00007325087,0.00005495346,0.00009971797,0.0001900983,0.0001120068],"category_scores_gemma":[0.00005778106,0.0002225744,0.00002485674,0.00119811,0.0001926579,0.000292091,0.00002392694,0.0002843068,0.00003243173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002430961,"about_ca_system_score_gemma":0.0001091172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00117542,"about_ca_topic_score_gemma":0.001839315,"domain_scores_codex":[0.9981836,0.0002567136,0.0005582997,0.0004643064,0.0002219322,0.0003151327],"domain_scores_gemma":[0.9992145,0.00005928794,0.0001302463,0.0003506005,0.00009823834,0.0001471339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002063244,0.0004289523,0.4931213,0.00001366388,0.000005329997,0.0001303376,0.002276208,0.00008567506,0.502137,0.00009258835,0.00006805753,0.001434518],"study_design_scores_gemma":[0.00282831,0.0003218986,0.8769832,0.0002122854,0.00001822647,0.00000661887,0.0005030222,0.0003928696,0.117362,0.0003327185,0.0008334562,0.0002054707],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940183,0.0031038,0.0000187231,0.001832479,0.00004965308,0.0007463685,0.00009508858,0.00006703004,0.00006862769],"genre_scores_gemma":[0.9974208,0.000153373,0.0005694556,0.0008008195,0.0001449954,0.0002985791,0.0005601002,0.00002781366,0.00002403859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3847751,"threshold_uncertainty_score":0.9076319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03358434931743611,"score_gpt":0.270083506410935,"score_spread":0.2364991570934989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}