{"id":"W2104675855","doi":"10.1093/nar/gkt213","title":"Impaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domain","year":2013,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Victoria","funders":"Canadian Institutes of Health Research","keywords":"Chromatin; Biology; MECP2; Cell biology; Molecular biology; DNA; Nucleosome; Mutant; Genetics; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001217181,0.0001084841,0.0001607032,0.0002693787,0.00005231559,0.00002073015,0.0005553671,0.0000977914,0.0001098736],"category_scores_gemma":[0.0002448384,0.00008818798,0.0000438511,0.0006979406,0.0001018058,0.000006050233,0.0002982577,0.0001631954,0.00002968322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000260414,"about_ca_system_score_gemma":0.00008007452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001244875,"about_ca_topic_score_gemma":0.0001224875,"domain_scores_codex":[0.9982915,0.0002663898,0.0003218958,0.0002856262,0.0004313083,0.0004032839],"domain_scores_gemma":[0.9994255,0.0000606507,0.00005168705,0.0003022434,0.00009823227,0.00006172437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002366567,0.00007333163,0.005628106,0.00004698146,0.00000729879,0.00000223686,0.001018024,0.00001568519,0.9916023,0.00004568203,0.0006323712,0.0009043255],"study_design_scores_gemma":[0.0004046269,0.0003063311,0.09894615,0.00006351075,7.471459e-7,0.000002239112,0.002625703,0.00005915327,0.8967717,0.0001399435,0.0005708812,0.0001090246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973828,0.0001059573,0.000009894359,0.0003157093,0.0000240144,0.0005820538,0.00001113609,0.000002003298,0.001566393],"genre_scores_gemma":[0.9987372,0.0001304642,0.0008373925,0.00004537401,0.000007336743,0.00007128745,0.000006156113,0.00001694796,0.0001478917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0948306,"threshold_uncertainty_score":0.3596201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03224837676525457,"score_gpt":0.318558488823911,"score_spread":0.2863101120586564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}