{"id":"W2104681220","doi":"10.1002/prot.22140","title":"The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide","year":2008,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; Hôtel-Dieu de Québec","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"PHD finger; H3K4me3; Histone code; Histone methylation; Histone H2A; Histone acetyltransferase; Histone H1; Chromatin; Histone deacetylase 2; Histone H3; Histone octamer; Chemistry; Histone; Chromatin remodeling; Histone methyltransferase; Nucleosome; SAP30; Epigenomics; Cell biology; Biology; Biochemistry; Zinc finger; Histone deacetylase; DNA methylation; Transcription factor; Promoter; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003313175,0.0007268224,0.0007788423,0.0002295492,0.001092651,0.000960944,0.001636527,0.0006034384,0.004370095],"category_scores_gemma":[0.000446937,0.0003584255,0.0002402339,0.0004692119,0.0004047332,0.0005400412,0.0006060099,0.001735095,0.0004790652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00222073,"about_ca_system_score_gemma":0.001165204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01463432,"about_ca_topic_score_gemma":0.01960661,"domain_scores_codex":[0.9996448,0.00001614299,0.000009891754,0.00006414929,0.000210403,0.00005454923],"domain_scores_gemma":[0.9998556,0.00002810599,0.00002217065,0.000004849895,0.00002710001,0.00006221875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007220962,0.002318102,0.03264304,0.003816522,0.001298102,0.009470147,0.001509659,0.04012451,0.6800658,0.01212403,0.0976366,0.1117726],"study_design_scores_gemma":[0.001843411,0.001959629,0.08946242,0.0003568011,0.0007540042,0.004192184,0.002325127,0.2318994,0.4835147,0.003900474,0.1793682,0.0004237296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9560713,0.01331504,0.008133497,0.001437077,0.0004463718,0.0001392804,0.004231872,0.0009624221,0.01526321],"genre_scores_gemma":[0.9593781,0.005115582,0.009514445,0.0005207297,0.0001139311,0.00007851765,0.01429746,0.0001373784,0.01084388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01463432,"threshold_uncertainty_score":0.02909827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007606657227627412,"score_gpt":0.1962631606104568,"score_spread":0.1886565033828294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}