{"id":"W2104721835","doi":"10.1161/01.res.87.12.1149","title":"Prolonged Hypercapnia-Evoked Cerebral Hyperemia via K<sup>+</sup>Channel– and Prostaglandin E<sub>2</sub>–Dependent Endothelial Nitric Oxide Synthase Induction","year":2000,"lang":"en","type":"article","venue":"Circulation Research","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Theratechnologies (Canada)","funders":"Medical Research Council; March of Dimes Foundation","keywords":"Nitric oxide synthase; Hypercapnia; Enos; Endocrinology; Internal medicine; Endothelial NOS; Chemistry; Acidosis; Respiratory acidosis; Nitric oxide; Vasodilation; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001897659,0.0003561893,0.0004621201,0.0001221641,0.0001040506,0.0003128725,0.0002374914,0.0003668617,0.0009567395],"category_scores_gemma":[0.0001284344,0.000170254,0.0005170405,0.00009403921,0.000372215,0.0003994084,0.0002694866,0.0004934229,0.0001911196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003852889,"about_ca_system_score_gemma":0.0003500254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005149804,"about_ca_topic_score_gemma":0.0008467727,"domain_scores_codex":[0.9998653,0.0000159378,0.00001001762,0.000029184,0.00002771182,0.00005186282],"domain_scores_gemma":[0.9998583,0.00001176522,0.00005974931,0.00001843003,0.00001686352,0.00003495301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007227883,0.00002192823,0.0002785324,0.00005948338,0.00001330318,0.0002193192,0.00001581083,0.00004125071,0.9974132,0.00009278948,0.00003541706,0.001086161],"study_design_scores_gemma":[0.0001083828,0.001932268,0.08910778,0.00002456056,0.00009866645,0.001476728,0.00008786604,0.002146365,0.9026409,0.0002698869,0.002086571,0.00001999399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881783,0.003987732,0.00611416,0.000145066,0.0001024964,0.000101804,0.0002214847,0.00008883486,0.001060231],"genre_scores_gemma":[0.9935643,0.001950971,0.0023447,0.00008418561,0.00007499937,0.0001720199,0.0003363224,0.00001193801,0.001460555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009567395,"threshold_uncertainty_score":0.00320065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03733174538841898,"score_gpt":0.2996440859829267,"score_spread":0.2623123405945078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}