{"id":"W2104721835","doi":"10.1161/01.res.87.12.1149","title":"Prolonged Hypercapnia-Evoked Cerebral Hyperemia via K<sup>+</sup>Channel– and Prostaglandin E<sub>2</sub>–Dependent Endothelial Nitric Oxide Synthase Induction","year":2000,"lang":"en","type":"article","venue":"Circulation Research","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Theratechnologies (Canada)","funders":"Medical Research Council; March of Dimes Foundation","keywords":"Nitric oxide synthase; Hypercapnia; Enos; Endocrinology; Internal medicine; Endothelial NOS; Chemistry; Acidosis; Respiratory acidosis; Nitric oxide; Vasodilation; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001796684,0.0003221297,0.0004751546,0.0008404326,0.0004452777,0.0001184483,0.0001482368,0.000368483,0.0003585853],"category_scores_gemma":[0.0005863078,0.0002930359,0.0001217693,0.001020106,0.0002382044,0.0003460746,0.00006920792,0.001049482,0.0005881013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003478121,"about_ca_system_score_gemma":0.0002516918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002839849,"about_ca_topic_score_gemma":0.00001173571,"domain_scores_codex":[0.9959142,0.0005861624,0.0004898836,0.000801448,0.001330576,0.0008777834],"domain_scores_gemma":[0.9981422,0.0003852692,0.00007568539,0.0005547315,0.0003725328,0.000469544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002558228,0.000634625,0.06887387,0.0004782076,0.0001805356,0.0003011714,0.0008721133,0.002097955,0.8286548,0.00004455815,0.0006588452,0.09464514],"study_design_scores_gemma":[0.02466014,0.001596753,0.5269505,0.0007167625,0.0004677581,0.003266883,0.001221632,0.1380468,0.2967403,0.003255208,0.001450047,0.001627182],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950777,0.0003305656,0.0001134275,0.0006108735,0.00006255852,0.002248479,0.00002994102,0.0001739244,0.001352487],"genre_scores_gemma":[0.9975547,0.0001855116,0.00008480473,0.0001193074,0.0006987808,0.0002699116,0.0001103531,0.00008095767,0.0008957143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5319145,"threshold_uncertainty_score":0.9999522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03733174538841898,"score_gpt":0.2996440859829267,"score_spread":0.2623123405945078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}