{"id":"W2104808226","doi":"10.1155/2013/130451","title":"Intracellular Regulation of Matrix Metalloproteinase-2 Activity: New Strategies in Treatment and Protection of Heart Subjected to Oxidative Stress","year":2013,"lang":"en","type":"review","venue":"Scientifica","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; Heart and Stroke Foundation of Canada","keywords":"Intracellular; Glycolysis; Oxidative stress; Ischemia; Myosin; Oxidative phosphorylation; Mitochondrion; Cell biology; Biochemistry; Reperfusion injury; Chemistry; Biology; Metabolism; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002164179,0.0002274766,0.0005986714,0.000223468,0.00003324398,0.00004075963,0.0001009281,0.0002277992,0.0000211127],"category_scores_gemma":[0.00004139718,0.0001837654,0.0001327795,0.0003360863,0.00006553066,0.0000154308,0.00006726986,0.00007210111,0.000004349819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000379946,"about_ca_system_score_gemma":0.0003455247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004663676,"about_ca_topic_score_gemma":0.0001108702,"domain_scores_codex":[0.9986972,0.0001702726,0.000348385,0.0004805901,0.0001414937,0.0001621045],"domain_scores_gemma":[0.9991865,0.000006741431,0.0002843618,0.0003589558,0.00008619545,0.00007727892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002274859,0.00008120075,3.076309e-7,0.0009995765,0.00004336854,2.722592e-7,0.00003020257,0.000003261525,0.8723444,0.00006015406,0.00002732853,0.1263872],"study_design_scores_gemma":[0.0001578405,0.0005340885,0.000006905462,0.001033774,0.00007983101,0.000002853742,0.00003265688,0.00000712333,0.9345077,0.000117754,0.06336693,0.000152553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2268445,0.7655577,0.002033788,0.00002991689,0.000192974,0.005151206,0.0001341548,0.00001197401,0.00004382762],"genre_scores_gemma":[0.2877866,0.6989295,0.006787216,0.000004009161,0.0003180299,0.001380984,0.0006783051,0.00009576601,0.00401957],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1262347,"threshold_uncertainty_score":0.7493734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.035795168896868,"score_gpt":0.3060311031402349,"score_spread":0.2702359342433668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}