{"id":"W2104851804","doi":"10.1093/infdis/jiq114","title":"An Ad5-Vectored HIV-1 Vaccine Elicits Cell-mediated Immunity but does not Affect Disease Progression in HIV-1–infected Male Subjects: Results From a Randomized Placebo-Controlled Trial (The Step Study)","year":2011,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Medicine; Placebo; Vaccination; HIV vaccine; Immunity; Immunology; Viral load; Lentivirus; Cellular immunity; AIDS Vaccines; Randomized controlled trial; Human immunodeficiency virus (HIV); Virology; Immune system; Vaccine trial; Internal medicine; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002993841,0.0009821909,0.00224943,0.0004208084,0.0003161007,0.0008554017,0.0006792684,0.001987949,0.004045786],"category_scores_gemma":[0.003185371,0.0004688102,0.001866079,0.0003475648,0.001128222,0.0006827153,0.0003025505,0.001562028,0.0003264143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003205075,"about_ca_system_score_gemma":0.0007363948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003838245,"about_ca_topic_score_gemma":0.0006451209,"domain_scores_codex":[0.9983926,0.001065034,0.00013798,0.0001677029,0.0001208873,0.0001157215],"domain_scores_gemma":[0.9983583,0.0007355803,0.0004331813,0.0001100611,0.00010676,0.0002560156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9692587,0.006176678,0.001394593,0.001324576,0.002039665,0.00003324634,0.00005963404,0.0001630972,0.003513972,0.00007335098,0.0002225954,0.01573994],"study_design_scores_gemma":[0.8100606,0.1835901,0.003654924,0.00008093901,0.00130066,0.00002428979,0.00002220421,0.0002035381,0.0007329185,0.00005885306,0.0002600066,0.00001092636],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994165,0.00345551,0.0003298553,0.000235689,0.0002214655,0.0009664748,0.0002379534,0.00003207571,0.0003560628],"genre_scores_gemma":[0.9937533,0.002252793,0.0008376356,0.0003652515,0.0004046923,0.001460464,0.0003007989,0.000008749595,0.0006163587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004045786,"threshold_uncertainty_score":0.01583314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103488154747488,"score_gpt":0.2632948452750624,"score_spread":0.2522599637275875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}