{"id":"W2104851804","doi":"10.1093/infdis/jiq114","title":"An Ad5-Vectored HIV-1 Vaccine Elicits Cell-mediated Immunity but does not Affect Disease Progression in HIV-1–infected Male Subjects: Results From a Randomized Placebo-Controlled Trial (The Step Study)","year":2011,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Medicine; Placebo; Vaccination; HIV vaccine; Immunity; Immunology; Viral load; Lentivirus; Cellular immunity; AIDS Vaccines; Randomized controlled trial; Human immunodeficiency virus (HIV); Virology; Immune system; Vaccine trial; Internal medicine; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002821282,0.0004775162,0.001484689,0.0003838075,0.0005395848,0.00006535008,0.0006647368,0.0001510712,0.0005973971],"category_scores_gemma":[0.003986473,0.0002054748,0.0005580646,0.0003388169,0.0002948972,0.0002657004,0.000134228,0.0008478186,0.0001940997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001542878,"about_ca_system_score_gemma":0.0004315994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001709593,"about_ca_topic_score_gemma":0.0007232952,"domain_scores_codex":[0.9858586,0.01162025,0.00132841,0.0003232506,0.0002674229,0.0006020705],"domain_scores_gemma":[0.9911171,0.006355899,0.001156018,0.0007830178,0.0003336566,0.000254327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9400975,0.01063688,0.0367736,0.00001312698,0.001730166,0.0002418449,0.002329952,0.00002905386,0.007506141,0.000001239253,0.000243767,0.0003967152],"study_design_scores_gemma":[0.8920044,0.004254848,0.0983409,0.0001120065,0.001857584,0.00002924571,0.0007950106,0.00005203528,0.002262226,0.00004243628,0.00001280308,0.0002364783],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891849,0.002018012,0.00003127881,0.000137052,0.0005798226,0.006958889,0.0008763096,0.00008581165,0.0001279121],"genre_scores_gemma":[0.9982735,0.000419369,0.000005980964,0.0000390745,0.0001782622,0.0004834089,0.0003461832,0.0000373914,0.0002168392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0615673,"threshold_uncertainty_score":0.8379018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103488154747488,"score_gpt":0.2632948452750624,"score_spread":0.2522599637275875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}