{"id":"W2104876332","doi":"10.1093/molbev/msr137","title":"Evolution of the TIR Domain-Containing Adaptors in Humans: Swinging between Constraint and Adaptation","year":2011,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Agence Nationale de la Recherche","keywords":"Biology; TRIF; Signal transducing adaptor protein; Innate immune system; Receptor; Toll-like receptor; Population; Genetics; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003085666,0.0001391217,0.0001689644,0.0004055483,0.0002357522,0.0002992332,0.000163993,0.0004034379,0.0008421415],"category_scores_gemma":[0.0005569158,0.0001047109,0.0001562701,0.0005175151,0.0005169181,0.0002256703,0.000300629,0.000274718,0.0001269142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001835863,"about_ca_system_score_gemma":0.0001289304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004790677,"about_ca_topic_score_gemma":0.0005367543,"domain_scores_codex":[0.9997966,0.0000462735,0.00001398486,0.00009547259,0.00002753394,0.00002025038],"domain_scores_gemma":[0.9998092,0.00004501475,0.00008119797,0.00001991195,0.00002301897,0.0000216648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009948909,0.00008749223,0.4713187,0.0002407447,0.0003464743,0.002202767,0.001686766,0.002284657,0.4037291,0.003998675,0.0005773705,0.1125325],"study_design_scores_gemma":[0.00003011568,0.0003162368,0.9652417,0.00004623169,0.0001005674,0.007731748,0.0005700647,0.001706911,0.0122002,0.003016358,0.008990007,0.00004989407],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953333,0.001821546,0.001736076,0.0001247349,0.000004892081,0.000005953812,0.000125132,0.0000152192,0.0008331457],"genre_scores_gemma":[0.9974174,0.0007754977,0.00128355,0.00009180641,0.00001420048,0.000006952673,0.0001161909,0.000009006536,0.0002854052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008421415,"threshold_uncertainty_score":0.002817273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01439630546674525,"score_gpt":0.226036600040358,"score_spread":0.2116402945736127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}