{"id":"W2104876332","doi":"10.1093/molbev/msr137","title":"Evolution of the TIR Domain-Containing Adaptors in Humans: Swinging between Constraint and Adaptation","year":2011,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Agence Nationale de la Recherche","keywords":"Biology; TRIF; Signal transducing adaptor protein; Innate immune system; Receptor; Toll-like receptor; Population; Genetics; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004849258,0.0001000391,0.0001670602,0.0001438765,0.000139957,0.000002476742,0.00006812695,0.0002501484,0.00001069957],"category_scores_gemma":[0.00007750167,0.0000839272,0.00003863971,0.0001094762,0.0003746421,0.00007080157,0.0000554104,0.0001663972,0.000003657429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005973885,"about_ca_system_score_gemma":0.00004867329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000367854,"about_ca_topic_score_gemma":0.00005224298,"domain_scores_codex":[0.9989417,0.0003829335,0.0002959949,0.0001786521,0.00001729747,0.0001834012],"domain_scores_gemma":[0.9996401,0.00004855308,0.0001479621,0.0001200146,0.00003452518,0.000008824687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001744054,0.00001733891,0.255774,0.0000137275,0.00005671206,8.739761e-7,0.002326128,0.000007169061,0.6719635,0.06541792,0.000002071986,0.004246179],"study_design_scores_gemma":[0.001048236,0.0002678699,0.9210445,0.0000895241,0.0000433692,0.0000195131,0.002363459,0.00006332468,0.05690512,0.01788931,0.0001173528,0.0001483774],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766791,0.003161088,0.01948152,0.00005214564,0.0001301719,0.0001803583,0.000003227861,0.00001472436,0.000297643],"genre_scores_gemma":[0.9995981,0.00002058749,0.000313093,0.00001269263,0.000008262631,0.000009958339,0.00002079495,0.000005181396,0.00001133932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6652706,"threshold_uncertainty_score":0.3422452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01439630546674525,"score_gpt":0.226036600040358,"score_spread":0.2116402945736127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}