{"id":"W2104938413","doi":"10.1073/pnas.0507370102","title":"Quantitative NMR spectroscopy of supramolecular complexes: Dynamic side pores in ClpP are important for product release","year":2005,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":213,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Protease; Chemistry; Substrate (aquarium); Relaxation (psychology); Nuclear magnetic resonance spectroscopy; Side chain; Biophysics; Spectroscopy; Crystallography; Enzyme; Stereochemistry; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002822904,0.0002450036,0.0001898656,0.0001249947,0.0002027438,0.0002496299,0.0002856192,0.0003799179,0.0008753088],"category_scores_gemma":[0.0005578341,0.0001399077,0.0001086374,0.0001394407,0.0003112739,0.0004540036,0.0002282758,0.0006103727,0.0001419603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001824198,"about_ca_system_score_gemma":0.0000862996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002159999,"about_ca_topic_score_gemma":0.0002399059,"domain_scores_codex":[0.9998901,0.00002023557,0.000003728692,0.00003298343,0.00003357562,0.00001934264],"domain_scores_gemma":[0.9997572,0.00007410995,0.00006935887,0.00002700213,0.00003817207,0.0000341141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005160092,0.000008843271,0.0001122681,0.00001970482,0.000002869339,0.00002977534,0.00002893006,0.0000866166,0.9989373,0.00008739631,0.00002414994,0.0006104829],"study_design_scores_gemma":[0.00002342545,0.0001767225,0.002863645,0.000007254708,0.000009255775,0.0001921491,0.00003662441,0.004516623,0.9911932,0.0002266469,0.0007442014,0.00001020144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860452,0.0007633516,0.01156092,0.0001254109,0.00001578023,0.00001779251,0.0001043459,0.0001146556,0.001252591],"genre_scores_gemma":[0.9935818,0.00028063,0.005096988,0.00006167923,0.0000107904,0.00002625853,0.0001216721,0.00002768908,0.0007925524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008753088,"threshold_uncertainty_score":0.002928138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02861109386525804,"score_gpt":0.3229257212183563,"score_spread":0.2943146273530982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}