{"id":"W2104982514","doi":"10.1006/jsre.2001.6326","title":"Hepatic Sinusoidal Endothelium Upregulates IL-1α, IFN-γ, and iNOS in Response to Discordant Xenogeneic Islets in an in Vitro Model of Xenoislet Transplantation","year":2002,"lang":"en","type":"article","venue":"Journal of Surgical Research","topic":"Xenotransplantation and immune response","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Endothelium; Islet; Transplantation; Biology; Endothelial stem cell; Cytokine; In vitro; Tumor necrosis factor alpha; Immunology; Endocrinology; Internal medicine; Molecular biology; Medicine; Biochemistry; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003673405,0.0003181736,0.0003593737,0.0002210601,0.0001517596,0.0003434252,0.0001510259,0.0002334303,0.001021748],"category_scores_gemma":[0.000229963,0.0001892089,0.0002243674,0.0001710374,0.000321953,0.0002221472,0.0001879994,0.0008733381,0.0002583069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001495097,"about_ca_system_score_gemma":0.0001141505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001498535,"about_ca_topic_score_gemma":0.0002209366,"domain_scores_codex":[0.9997109,0.0001022079,0.00003920857,0.00003688956,0.00005224995,0.00005859792],"domain_scores_gemma":[0.9996722,0.00008421895,0.00007878458,0.00008685201,0.00001989146,0.00005812369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001874281,0.0002041057,0.0005742591,0.00005294572,0.000008589027,0.0002170791,0.00006163056,0.0001396286,0.9960811,0.0001048877,0.00002618989,0.0006554186],"study_design_scores_gemma":[0.00007749351,0.001544122,0.007406431,0.000008333163,0.00003676782,0.0003268565,0.0001421261,0.001078048,0.9888177,0.000080386,0.0004754211,0.000006378087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988217,0.0002343977,0.0004366036,0.00002398736,0.00003399453,0.000007803114,0.00004435821,0.000009608509,0.0003876258],"genre_scores_gemma":[0.9983464,0.0002574193,0.0005832412,0.00003587547,0.0000268452,0.0000166848,0.0001238121,0.00000488625,0.0006046701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001021748,"threshold_uncertainty_score":0.003418088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0755545220013201,"score_gpt":0.3695948195426164,"score_spread":0.2940402975412962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}