{"id":"W2105000893","doi":"10.1186/1471-2164-14-854","title":"Kinotypes: stable species- and individual-specific profiles of cellular kinase activity","year":2013,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Genome Canada","keywords":"Kinome; Biology; Computational biology; Kinase; Evolutionary biology; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006044859,0.0001285667,0.0001646584,0.00002952042,0.00007668577,0.00003865138,0.0001811998,0.00009478413,0.0004742913],"category_scores_gemma":[0.000009175361,0.0001316735,0.00004170871,0.00006289493,0.00009206443,0.00009210545,0.0001362044,0.000130154,0.00002097112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000495056,"about_ca_system_score_gemma":0.00003780896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005411196,"about_ca_topic_score_gemma":0.00000485064,"domain_scores_codex":[0.9993046,0.00000721202,0.0001801085,0.000242489,0.00008613872,0.0001794413],"domain_scores_gemma":[0.9992875,0.00004420938,0.0001464044,0.0004070652,0.00005098876,0.00006381804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008348903,0.0000545485,0.002370289,0.00008388171,0.000007782078,2.457728e-7,0.00007524074,0.00001762308,0.9918573,0.00277102,0.000315004,0.002438749],"study_design_scores_gemma":[0.0001515744,0.000009959345,0.001333521,0.0000104974,0.000009028985,0.000001110356,0.0001193395,0.0001599051,0.9734572,0.004243515,0.02035356,0.0001507896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668621,0.0003403402,0.02858959,0.00003172992,0.0000108337,0.0003018419,0.0001222435,0.00005908856,0.003682164],"genre_scores_gemma":[0.8952333,0.0002797811,0.1033121,0.000009063363,0.00006826076,0.0001414952,0.00003386535,0.0000257456,0.0008963758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07472248,"threshold_uncertainty_score":0.536949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0315674269544825,"score_gpt":0.2372143443084969,"score_spread":0.2056469173540144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}