{"id":"W2105004746","doi":"10.1002/ejoc.200801184","title":"Synthesis of <i>exo</i>‐3‐Amino‐7‐azabicyclo[2.2.1]heptanes as a Class of Malarial Aspartic Protease Inhibitors: Exploration of Two Binding Pockets","year":2009,"lang":"en","type":"article","venue":"European Journal of Organic Chemistry","topic":"Malaria Research and Control","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Chemistry; Proteases; Enzyme; Stereochemistry; Protease; Peptidomimetic; Plasmodium falciparum; Combinatorial chemistry; Biochemistry; Peptide; Malaria; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001229653,0.0001917777,0.0006298904,0.000122076,0.0000337459,0.00001714738,0.000269782,0.00005570425,0.0007036491],"category_scores_gemma":[0.002482315,0.0001629842,0.0002509602,0.0002990577,0.0001119992,0.0002158291,0.00004852214,0.0003977757,0.00001118584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006545547,"about_ca_system_score_gemma":0.0004392652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002375466,"about_ca_topic_score_gemma":2.179129e-7,"domain_scores_codex":[0.9973859,0.0002385617,0.001184064,0.0001767411,0.0007522013,0.0002625452],"domain_scores_gemma":[0.9975824,0.0001113685,0.001133888,0.0003391137,0.0005359668,0.00029729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001478446,0.0004588039,0.0003850362,0.0003503828,0.0001595723,0.0004143812,0.0002334677,0.000005152194,0.9911097,0.00002431774,0.0002814839,0.005099269],"study_design_scores_gemma":[0.003731329,0.0009463021,0.001751296,0.001026702,0.0002723081,0.0004185798,0.0003523351,0.00001996111,0.9911486,0.00007521083,0.0001386923,0.0001187102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923611,0.0002154528,0.0001341465,0.001897809,0.00006775706,0.0002371528,0.000009426538,0.00001146589,0.005065683],"genre_scores_gemma":[0.998612,0.00004839191,0.0003657099,0.00003230403,0.0006513836,0.000001412543,0.000003179373,0.00003302486,0.0002526122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006250876,"threshold_uncertainty_score":0.7704464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172933980938852,"score_gpt":0.2594895557201962,"score_spread":0.242196157626311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}