{"id":"W2105004746","doi":"10.1002/ejoc.200801184","title":"Synthesis of <i>exo</i>‐3‐Amino‐7‐azabicyclo[2.2.1]heptanes as a Class of Malarial Aspartic Protease Inhibitors: Exploration of Two Binding Pockets","year":2009,"lang":"en","type":"article","venue":"European Journal of Organic Chemistry","topic":"Malaria Research and Control","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Chemistry; Proteases; Enzyme; Stereochemistry; Protease; Peptidomimetic; Plasmodium falciparum; Combinatorial chemistry; Biochemistry; Peptide; Malaria; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040404,0.0002938378,0.0002453837,0.0001487026,0.000125802,0.0001926174,0.000203033,0.000214153,0.00247002],"category_scores_gemma":[0.00008879233,0.0001328908,0.0001579076,0.0001442435,0.0001126494,0.000194862,0.0001818193,0.0002674943,0.001002327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001881912,"about_ca_system_score_gemma":0.0003576246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002401139,"about_ca_topic_score_gemma":0.0003850409,"domain_scores_codex":[0.999927,0.00001316923,0.000006311715,0.0000119317,0.00001568548,0.00002579549],"domain_scores_gemma":[0.9999583,0.000005512703,0.000009443908,0.000003335992,0.000007726101,0.0000156816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002021149,0.00007048017,0.0001211751,0.0003692474,0.00001356918,0.0002887871,0.000047694,0.00113305,0.9828844,0.002212172,0.0004362277,0.01222104],"study_design_scores_gemma":[0.0001026699,0.001435271,0.00128395,0.00002732283,0.00002305608,0.0004250827,0.0000348565,0.001921622,0.9777725,0.0003904229,0.01655341,0.0000298086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9366946,0.005373887,0.02081856,0.0002502959,0.0003171106,0.0004111358,0.001331902,0.0004119699,0.03439051],"genre_scores_gemma":[0.9735342,0.003976698,0.01344321,0.0001514428,0.00004866609,0.000223968,0.0008958225,0.00006235265,0.007663622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00247002,"threshold_uncertainty_score":0.008263052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172933980938852,"score_gpt":0.2594895557201962,"score_spread":0.242196157626311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}