{"id":"W2105018942","doi":"10.1128/jvi.78.4.1706-1717.2004","title":"Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus Replication","year":2004,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":202,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Biology; IRF3; Virus; Virology; Interferon; Vesicular stomatitis virus; Viral replication; IRF7; Innate immune system; Sendai virus; DNA virus; Viral entry; Sindbis virus; Viral transformation; Ectromelia virus; Interferon regulatory factors; Antibody-dependent enhancement; Vaccinia; RNA; Immune system; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002479938,0.0003277023,0.0002915924,0.00021282,0.0002856808,0.0003918073,0.0002247795,0.0004408463,0.00235333],"category_scores_gemma":[0.0002415071,0.0001245519,0.0006350015,0.0001504489,0.0002739929,0.0004208157,0.0003789646,0.0009323499,0.001307729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005228105,"about_ca_system_score_gemma":0.0003902205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005635676,"about_ca_topic_score_gemma":0.0005714001,"domain_scores_codex":[0.9997447,0.00002575871,0.00002260803,0.00005759152,0.0000616148,0.00008764063],"domain_scores_gemma":[0.9997916,0.00003670157,0.00005774271,0.00004862094,0.00003394554,0.00003153417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001303252,0.00001985314,0.0005272967,0.00004634315,0.00000460792,0.00005892284,0.00001515971,0.00002663632,0.9976044,0.0001274732,0.00006292087,0.001376066],"study_design_scores_gemma":[0.00002231622,0.0002659841,0.02860717,0.00001700055,0.00001346645,0.0009915148,0.00005417964,0.0005310986,0.9654129,0.0002722502,0.003798518,0.00001356413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840222,0.004188213,0.006492589,0.0002306218,0.0001077875,0.00005725426,0.001147745,0.0002785868,0.003475053],"genre_scores_gemma":[0.9935574,0.0008381812,0.002722871,0.0001057466,0.00003359473,0.00004480616,0.001283388,0.00002121859,0.001392809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00235333,"threshold_uncertainty_score":0.007872701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01765456512458191,"score_gpt":0.2745765140108294,"score_spread":0.2569219488862475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}