{"id":"W2105021051","doi":"","title":"Silibinin up-regulates insulin-like growth factor-binding protein 3 expression and inhibits proliferation of androgen-independent prostate cancer cells.","year":2000,"lang":"en","type":"article","venue":"PubMed","topic":"Silymarin and Mushroom Poisoning","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Silibinin; Growth factor; Endocrinology; Androgen receptor; Internal medicine; Prostate cancer; Cancer research; Insulin-like growth factor; Chemistry; Cell growth; Biology; Receptor; Medicine; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002155924,0.0002060211,0.0003165535,0.0001324643,0.00009391987,0.00003833396,0.00005827687,0.0001342387,0.0001035654],"category_scores_gemma":[0.00004858773,0.0001693208,0.00005136017,0.000181615,0.00006248678,0.0002215997,0.00004765794,0.0001865055,0.000004249857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009079551,"about_ca_system_score_gemma":0.00008334115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008665853,"about_ca_topic_score_gemma":0.00001613972,"domain_scores_codex":[0.9984527,0.00005526999,0.0003731516,0.0003755296,0.0003509057,0.0003924129],"domain_scores_gemma":[0.9993522,0.00002447944,0.0001412347,0.0001708395,0.00009357961,0.0002176954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001006351,0.0001893533,0.06102062,0.0004738019,0.00007158068,0.00001342966,0.002429437,0.000008622612,0.6612527,0.00001739173,0.0001780768,0.2733386],"study_design_scores_gemma":[0.002622468,0.0000732419,0.07667791,0.0002486714,0.00003539622,0.00001472702,0.00008613765,0.00007311905,0.9196324,0.00002129191,0.0003440721,0.0001705646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959997,0.0005372805,0.00000144117,0.0001646392,0.0001518932,0.002603796,0.00002099627,0.00007649063,0.0004437443],"genre_scores_gemma":[0.992725,0.0002796489,0.00009928024,0.00005361736,0.00009005109,0.001373296,0.00002473927,0.00003558273,0.005318849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2731681,"threshold_uncertainty_score":0.69047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01525465473864612,"score_gpt":0.2282605729014091,"score_spread":0.213005918162763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}