{"id":"W2105026490","doi":"10.1200/jco.2007.14.8924","title":"Role of <i>KRAS</i> and <i>EGFR</i> As Biomarkers of Response to Erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":665,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Queen's University; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"Erlotinib; KRAS; Medicine; Epidermal growth factor receptor; Hazard ratio; Fluorescence in situ hybridization; EGFR inhibitors; Internal medicine; Oncology; Erlotinib Hydrochloride; Cancer research; Cancer; Biology; Gene; Colorectal cancer; Genetics; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01126488,0.001165673,0.002877533,0.0005048424,0.0004240123,0.001444116,0.0009821291,0.001302485,0.001499469],"category_scores_gemma":[0.01023589,0.0004610076,0.001625836,0.0006750019,0.0008299541,0.000684068,0.0003487437,0.00166384,0.0002497151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001690491,"about_ca_system_score_gemma":0.002224728,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00553385,"about_ca_topic_score_gemma":0.01779223,"domain_scores_codex":[0.9934108,0.004954733,0.0002902422,0.0004672758,0.0005901512,0.000286884],"domain_scores_gemma":[0.9888681,0.00407324,0.004328573,0.0006476094,0.0008996158,0.001182983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7869942,0.001184631,0.1616691,0.001041092,0.00574119,0.00007763504,0.0001131107,0.001268893,0.003902092,0.0001725677,0.0018172,0.03601817],"study_design_scores_gemma":[0.2079644,0.05621645,0.7136186,0.0003902522,0.0101719,0.0003530853,0.00008852213,0.004568655,0.001890391,0.0004175646,0.004159176,0.0001609952],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699633,0.02339418,0.0004280882,0.0007878997,0.0001161657,0.0007277954,0.001784986,0.00004632616,0.002751273],"genre_scores_gemma":[0.9947149,0.001304972,0.0006282188,0.0005155032,0.0001438958,0.0005109531,0.001515596,0.00001890279,0.0006470964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9944661,"threshold_uncertainty_score":0.05957508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1692448192514435,"score_gpt":0.5560504929225468,"score_spread":0.3868056736711033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}