{"id":"W2105057212","doi":"10.1126/science.1106914","title":"Gene Regulation at the Single-Cell Level","year":2005,"lang":"en","type":"article","venue":"Science","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1130,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System","funders":"","keywords":"Gene; Reporter gene; Biology; Function (biology); Escherichia coli; Fusion gene; Transcription (linguistics); Fusion protein; Computational biology; Cell biology; Limiting; Green fluorescent protein; Transcription factor; Cell; Genetics; Gene expression; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003641408,0.00006653745,0.00004606332,0.00002683192,0.0002793586,0.00002835761,0.0003023948,0.00003545693,0.00005073959],"category_scores_gemma":[0.00002307043,0.00004816601,0.00004622469,0.0002756739,0.0003347503,0.00000475609,0.0001686703,0.00002381613,0.00006796397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000448133,"about_ca_system_score_gemma":0.0000635324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001605108,"about_ca_topic_score_gemma":0.00006141107,"domain_scores_codex":[0.9991801,0.00002055381,0.00009400366,0.0002870314,0.0002191342,0.000199136],"domain_scores_gemma":[0.9993827,0.000003987833,0.00005130853,0.0004400143,0.0000695957,0.00005241714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000002902466,0.00001171735,0.0005513217,4.760788e-7,0.000002410634,7.839571e-8,0.00001753328,0.004819112,0.9863942,0.000006206543,0.001171927,0.007022157],"study_design_scores_gemma":[0.00006937148,0.00002264498,0.01083345,7.511657e-7,0.000007687482,0.00000583481,0.000008567648,0.001001898,0.9375763,0.00002026641,0.05038195,0.00007130942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952614,0.0008560007,0.001282838,0.0004581807,0.0000641891,0.0000522313,0.000001929695,0.00000589501,0.002017309],"genre_scores_gemma":[0.9879581,0.00001738679,0.001497139,0.0002279733,0.0002389178,0.000002809495,0.000009849603,0.000005563597,0.0100422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04921002,"threshold_uncertainty_score":0.2148629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02018384961383521,"score_gpt":0.2349622722649972,"score_spread":0.214778422651162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}