{"id":"W2105057579","doi":"10.1196/annals.1306.007","title":"Heme Oxygenase‐1: Transducer of Pathological Brain Iron Sequestration under Oxidative Stress","year":2004,"lang":"en","type":"review","venue":"Annals of the New York Academy of Sciences","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Oxidative stress; Heme oxygenase; Heme; Proinflammatory cytokine; Biliverdin; Neuroinflammation; Chemistry; Reactive oxygen species; Oxidative phosphorylation; Biochemistry; Biology; Inflammation; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008518161,0.0003085824,0.0007903982,0.00008319786,0.00007284377,0.00001251637,0.001112004,0.0005749171,0.00001887198],"category_scores_gemma":[0.0001124083,0.0001911113,0.0006077514,0.0004098997,0.0009747658,0.00001139985,0.000123271,0.0002561584,0.000001378216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008873688,"about_ca_system_score_gemma":0.0005475695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003526234,"about_ca_topic_score_gemma":0.000005210058,"domain_scores_codex":[0.997689,0.000289452,0.0007599941,0.0005057756,0.0004575587,0.0002981954],"domain_scores_gemma":[0.9987401,0.00006485418,0.0008415168,0.0002064719,0.00004800164,0.0000990917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001251433,0.0006992879,0.00005971532,0.01331638,0.0006484595,0.000002332288,0.0005769861,0.001608309,0.5323414,0.01372278,0.01260268,0.4242965],"study_design_scores_gemma":[0.0002973692,0.0007539216,0.0002177239,0.006368393,0.0002284885,0.00001521302,0.0002209481,0.000002718009,0.8293287,0.003535344,0.158477,0.0005542088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03212707,0.9650187,0.00006769472,0.001780101,0.00006362741,0.0004631032,0.0001630662,0.00000598482,0.0003106153],"genre_scores_gemma":[0.07737249,0.9212226,0.0003691702,0.000463964,0.0001745685,0.00001256476,0.00003170522,0.00001896948,0.0003339996],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4237423,"threshold_uncertainty_score":0.7793292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1229576989280308,"score_gpt":0.3807966526676151,"score_spread":0.2578389537395843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}