{"id":"W2105057579","doi":"10.1196/annals.1306.007","title":"Heme Oxygenase‐1: Transducer of Pathological Brain Iron Sequestration under Oxidative Stress","year":2004,"lang":"en","type":"review","venue":"Annals of the New York Academy of Sciences","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Oxidative stress; Heme oxygenase; Heme; Proinflammatory cytokine; Biliverdin; Neuroinflammation; Chemistry; Reactive oxygen species; Oxidative phosphorylation; Biochemistry; Biology; Inflammation; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003158133,0.0006844035,0.000829385,0.001252899,0.0002751461,0.000787362,0.0006358051,0.001061898,0.001755804],"category_scores_gemma":[0.0002900914,0.0001804432,0.0001598362,0.001412215,0.0004280764,0.001094837,0.0003207294,0.001051971,0.002536811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006110593,"about_ca_system_score_gemma":0.0007771431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007525259,"about_ca_topic_score_gemma":0.001276702,"domain_scores_codex":[0.9999311,0.00001177063,0.00000763302,0.00001550318,0.00002558067,0.000008397179],"domain_scores_gemma":[0.9999081,0.00002752541,0.00001434071,0.000003217701,0.00003118246,0.00001566183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001271701,0.00007322753,0.0003205012,0.005769492,0.00003940869,0.0004059149,0.00008967337,0.0003443602,0.005888166,0.004026532,0.03133038,0.9515852],"study_design_scores_gemma":[0.0000242866,0.00009567156,0.001310694,0.001050555,0.00004156146,0.002200975,0.00008185408,0.00009848744,0.00126932,0.002121015,0.9916917,0.0000139609],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002916732,0.9974691,0.0002297613,0.0002975326,0.0002403365,0.000004991893,0.0000102607,0.00001069821,0.001445761],"genre_scores_gemma":[0.0014267,0.9960098,0.0002733613,0.0002094989,0.0002039845,0.0000088745,0.0000239022,0.000001633294,0.001842191],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001755804,"threshold_uncertainty_score":0.00587374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1229576989280308,"score_gpt":0.3807966526676151,"score_spread":0.2578389537395843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}