{"id":"W2105087340","doi":"10.1111/j.1600-065x.2009.00764.x","title":"The role of costimulation in antibody deficiencies: ICOS and common variable immunodeficiency","year":2009,"lang":"en","type":"review","venue":"Immunological Reviews","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Common variable immunodeficiency; Immunology; Primary immunodeficiency; Biology; Disease; Immunodeficiency; Immune system; Antibody; Germinal center; B cell; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004123295,0.000819766,0.0009860346,0.001200597,0.0001949363,0.0004658121,0.0007019339,0.0010341,0.001149484],"category_scores_gemma":[0.0004044722,0.000151229,0.0001909604,0.001100642,0.0004209579,0.0007385295,0.0003583886,0.001089772,0.001213443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005001528,"about_ca_system_score_gemma":0.0004416582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007140862,"about_ca_topic_score_gemma":0.0008901898,"domain_scores_codex":[0.9998561,0.00002810857,0.00002302133,0.00002677431,0.00005380019,0.00001227439],"domain_scores_gemma":[0.9998424,0.00006889421,0.00002502618,0.000005270715,0.00004056111,0.0000177953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009935796,0.00004020064,0.0004569089,0.005675447,0.00006771477,0.0007927761,0.00006494315,0.0003509451,0.004621974,0.004702504,0.03210722,0.9510199],"study_design_scores_gemma":[0.00003246247,0.0001184453,0.002149151,0.001603612,0.00007613379,0.009061903,0.00007582222,0.000172443,0.0017657,0.00302104,0.9819053,0.00001786338],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002116764,0.9982859,0.0001770328,0.0002467491,0.0002662281,0.000002008667,0.000004354502,0.000006140856,0.0007998699],"genre_scores_gemma":[0.002443035,0.9951798,0.0002818182,0.0003377102,0.0004783873,0.000006368356,0.00001860499,0.000001862685,0.001252498],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001200597,"threshold_uncertainty_score":0.003845394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02637777862409918,"score_gpt":0.3285651774521442,"score_spread":0.302187398828045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}