{"id":"W2105100844","doi":"10.1056/nejmoa043331","title":"<i>MGMT</i> Gene Silencing and Benefit from Temozolomide in Glioblastoma","year":2005,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":7252,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Temozolomide; Medicine; O-6-methylguanine-DNA methyltransferase; Methyltransferase; Hazard ratio; Oncology; Methylation; Confidence interval; DNA methylation; Internal medicine; Radiation therapy; Cancer research; DNA methyltransferase; Biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009082093,0.0001821633,0.0005936535,0.0001604234,0.00006757632,0.0001934821,0.0001486893,0.0002067995,0.0005508032],"category_scores_gemma":[0.0009978733,0.00008006892,0.0003696934,0.0001353817,0.0002380371,0.0001280022,0.0001237063,0.0003474268,0.00005613821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003289447,"about_ca_system_score_gemma":0.0004006922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005611823,"about_ca_topic_score_gemma":0.001138266,"domain_scores_codex":[0.9998091,0.00009814784,0.00001896615,0.00001893182,0.00002576387,0.00002918834],"domain_scores_gemma":[0.9995852,0.0001504963,0.0001329031,0.0000168533,0.00002017559,0.00009447298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4509661,0.003111425,0.217445,0.001508645,0.002703228,0.0006016926,0.000164023,0.005151279,0.07620648,0.00035285,0.002215013,0.2395744],"study_design_scores_gemma":[0.03280804,0.1793567,0.7471943,0.0001747968,0.004062438,0.001633434,0.0001196101,0.007814117,0.02216137,0.000979515,0.00365439,0.00004126154],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980047,0.001618312,0.00005873908,0.000124215,0.000014306,0.00001614217,0.00003935508,0.000004533698,0.0001196787],"genre_scores_gemma":[0.998976,0.0006432749,0.0001156418,0.00008812836,0.00002104104,0.00001695607,0.00008395533,0.000001327949,0.00005366867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009082093,"threshold_uncertainty_score":0.004803121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129808041401682,"score_gpt":0.2508328307641014,"score_spread":0.2395347503500846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}