{"id":"W2105116541","doi":"10.1128/jb.01433-10","title":"Characterization of a Zinc-Containing Alcohol Dehydrogenase with Stereoselectivity from the Hyperthermophilic Archaeon Thermococcus guaymasensis","year":2011,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Alcohol dehydrogenase; Homotetramer; Acetoin; Thermococcus; Enzyme; Biology; Dehydrogenase; Zinc; Biochemistry; Stereoselectivity; Enzyme assay; Stereochemistry; Protein subunit; Chemistry; Catalysis; Organic chemistry; Gene; Fermentation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007378866,0.0002326302,0.0002850708,0.0002560714,0.00009532834,0.0002898006,0.0001244465,0.0001735595,0.000331405],"category_scores_gemma":[0.0002026942,0.00009325302,0.00018246,0.0002408189,0.0001456477,0.0001248515,0.0001914605,0.0001610475,0.00019855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001634176,"about_ca_system_score_gemma":0.000168729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002331233,"about_ca_topic_score_gemma":0.001479936,"domain_scores_codex":[0.9999405,0.00000701276,0.000006478596,0.00001787042,0.0000193448,0.000008867961],"domain_scores_gemma":[0.9998899,0.0000117739,0.00002445069,0.00001069878,0.00002827013,0.00003492303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005935543,0.00001051825,0.002109928,0.0000402851,0.000005317124,0.0001245108,0.00005455962,0.00003160302,0.9957262,0.00002451365,0.00001300287,0.001800117],"study_design_scores_gemma":[0.00002794665,0.0003049027,0.1489335,0.0000189706,0.00005533142,0.002191047,0.0003254509,0.001507768,0.8398622,0.0001275946,0.006621114,0.00002409023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975617,0.0006291991,0.001059372,0.00007684108,0.000006901131,0.00001257473,0.0003489341,0.00002380142,0.0002806825],"genre_scores_gemma":[0.9943315,0.000419578,0.002324252,0.00003646328,0.000009842997,0.00001007551,0.001629509,0.0000172839,0.00122152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002331233,"threshold_uncertainty_score":0.004635394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01981570866520983,"score_gpt":0.2238108783463239,"score_spread":0.203995169681114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}