{"id":"W2105164237","doi":"10.1111/j.1365-2958.2012.08017.x","title":"The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in <i>Candida albicans</i>","year":2012,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Vlaamse regering; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Universitat de València; Fonds Wetenschappelijk Onderzoek","keywords":"Septin; Biology; Candida albicans; Defensin; Yeast; Cell biology; Microbiology; Cell wall; Cell; Biochemistry; Cell division","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009034162,0.0003490956,0.0001975541,0.0001681603,0.0001441042,0.0002576696,0.0002125744,0.0002633872,0.0007631613],"category_scores_gemma":[0.00008091562,0.0001433423,0.0001964325,0.0001380845,0.0001422637,0.0001012427,0.0001800114,0.0005388285,0.0002674869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003222561,"about_ca_system_score_gemma":0.0001300814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007832133,"about_ca_topic_score_gemma":0.0008329529,"domain_scores_codex":[0.9998796,0.00001646859,0.00001264686,0.00002446511,0.00003578738,0.0000311094],"domain_scores_gemma":[0.9999032,0.00001715233,0.00002659846,0.00001144635,0.00000906758,0.00003256771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003309812,0.000007675999,0.00005363611,0.000007073795,0.000001291446,0.00002583844,0.000002819111,0.00001095739,0.9996513,0.00001135023,0.00001167017,0.0001832202],"study_design_scores_gemma":[0.000005967465,0.00009289811,0.004097938,0.00000278538,0.00000555033,0.0002117928,0.00001681591,0.0003783476,0.994499,0.00001410154,0.0006721993,0.000002600417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980797,0.0003214983,0.0005378926,0.00005333934,0.000007812501,0.000008939463,0.0003562771,0.00003455885,0.0006000448],"genre_scores_gemma":[0.9957395,0.0002550053,0.001331046,0.00006979259,0.000005409454,0.00001964875,0.001093139,0.00002678751,0.001459723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007832133,"threshold_uncertainty_score":0.002552986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01613550439591535,"score_gpt":0.2319435767427632,"score_spread":0.2158080723468479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}