{"id":"W2105172870","doi":"10.1001/archneurol.2010.108","title":"Genetic Variation and Neuroimaging Measures in Alzheimer Disease","year":2010,"lang":"en","type":"article","venue":"Archives of Neurology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; University of California, San Diego; University of California, Los Angeles; National Institutes of Health; Eisai; National Center for Research Resources; Elan; GlaxoSmithKline; Pfizer; National Institute on Drug Abuse; Eli Lilly and Company; Bristol-Myers Squibb; Ellison Medical Foundation; American Heart Association; National Institute on Aging; Alzheimer's Association; National Institute of Neurological Disorders and Stroke; Northern California Institute for Research and Education; Howard Hughes Medical Institute; Foundation for the National Institutes of Health","keywords":"Genome-wide association study; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Parahippocampal gyrus; False discovery rate; Brain size; Psychology; White matter; Neuroscience; Dementia; Medicine; Magnetic resonance imaging; Disease; Internal medicine; Biology; Single-nucleotide polymorphism; Temporal lobe; Genetics; Genotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001471138,0.0004491044,0.0003195577,0.0006514222,0.0002184076,0.0003978206,0.0003308992,0.0003418006,0.001090007],"category_scores_gemma":[0.006715504,0.0001180993,0.000282747,0.0008647487,0.0004068837,0.0002171544,0.0003030248,0.0002480865,0.00008291501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002139194,"about_ca_system_score_gemma":0.0002122184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00198126,"about_ca_topic_score_gemma":0.002203795,"domain_scores_codex":[0.9990845,0.0004126558,0.00007658915,0.0002500054,0.0001373082,0.0000389599],"domain_scores_gemma":[0.9970813,0.001134502,0.001369406,0.0001580858,0.000130855,0.0001258156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006294926,0.00007172283,0.9913161,0.00006393199,0.0005917312,0.0003256922,0.0000961733,0.0002630241,0.00195964,0.0001450687,0.0001259743,0.004411405],"study_design_scores_gemma":[0.000020281,0.00008863556,0.9987515,0.000007909651,0.00007908032,0.0003988532,0.00002298528,0.0001904209,0.0001685601,0.0001715417,0.00009698267,0.000003161361],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976955,0.001045109,0.0003641432,0.0001086612,0.000007612897,0.00001092117,0.0004047328,0.000007708117,0.0003554803],"genre_scores_gemma":[0.9991683,0.0001317514,0.0003908128,0.00002767948,0.00001561628,0.00001008742,0.0001963876,0.000002178925,0.00005733615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00198126,"threshold_uncertainty_score":0.007780194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01196499143876502,"score_gpt":0.2472268439256851,"score_spread":0.2352618524869201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}