{"id":"W2105201864","doi":"10.2217/pme.09.21","title":"‘Principled‘ Personalized Medicine?","year":2009,"lang":"en","type":"article","venue":"Personalized Medicine","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"Genome Canada","keywords":"Personalized medicine; Medicine; Precision medicine; Bioinformatics; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06048458,0.0008256548,0.001683569,0.00113733,0.00263215,0.008753871,0.003173372,0.01353794,0.008264822],"category_scores_gemma":[0.06037753,0.0008316776,0.0009253695,0.001120239,0.05119125,0.01832758,0.00819164,0.01849074,0.003045109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005646137,"about_ca_system_score_gemma":0.009256676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001464373,"about_ca_topic_score_gemma":0.001430052,"domain_scores_codex":[0.9508232,0.03296747,0.001666519,0.003821429,0.00917794,0.001543424],"domain_scores_gemma":[0.9666665,0.02032516,0.002010736,0.006745587,0.002734464,0.001517567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00003055813,0.00002728714,0.0002168725,0.0002711923,0.00004478846,0.00009364712,0.001906833,0.0003793793,0.0002077329,0.9093209,0.05491364,0.03258713],"study_design_scores_gemma":[0.00001829204,0.00001308712,0.0001230132,0.0002815539,0.000008907467,0.0001641076,0.00041623,0.0002046183,0.0001385803,0.8358912,0.1627215,0.00001882527],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001405692,0.02064809,0.04379817,0.8933252,0.005940689,0.00005983983,0.00009012188,0.000155908,0.03457638],"genre_scores_gemma":[0.2658181,0.02673594,0.08481132,0.5845643,0.01868193,0.0005515019,0.0003219089,0.0002922852,0.0182227],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.06048458,"threshold_uncertainty_score":0.3198769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02330363367193054,"score_gpt":0.3251554778271835,"score_spread":0.301851844155253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}