{"id":"W2105206040","doi":"10.1212/wnl.0000000000000560","title":"Defining the clinical course of multiple sclerosis","year":2014,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":3133,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; EMD Serono; Acorda Therapeutics; University of Cambridge; Bayer Canada; National Institutes of Health; Multiple Sclerosis Society; Schweizerische Multiple Sklerose Gesellschaft; Eisai; National Institute for Health and Care Research; National Research Foundation; Wolfson Foundation; Genentech; European Commission; Glenmark Pharmaceuticals; Multiple Sclerosis International Federation; Sanofi; GW Pharmaceuticals; Alexion Pharmaceuticals; Myelin Repair Foundation; Bayer HealthCare; Grifols; F. Hoffmann-La Roche; Ironwood Pharmaceuticals, Incorporated; Eli Lilly and Company; University of Alabama; Wellcome Trust; European Committee for Treatment and Research in Multiple Sclerosis; Sanofi Genzyme; University of Alabama at Birmingham; Medical Research Council; Teva Pharmaceutical Industries; Gilead Sciences; GlaxoSmithKline; University of Texas Health Science Center at Houston; Celgene; Natural Sciences and Engineering Research Council of Canada; Pfizer; Biogen; Serono Symposia International Foundation; Novartis Pharmaceuticals Corporation; National Multiple Sclerosis Society; National Heart, Lung, and Blood Institute; Sun Pharma; Cleveland Clinic; Canadian Institutes of Health Research; Prothena; Amylin Pharmaceuticals","keywords":"Multiple sclerosis; Clinical trial; Clinical phenotype; Disease; Medicine; Clinical disease; Phenotype; Medical physics; Pathology; Intensive care medicine; Bioinformatics; Biology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003581472,0.0004316525,0.0004934911,0.002192836,0.0004431016,0.001665893,0.0006163659,0.0006354619,0.001155982],"category_scores_gemma":[0.01036604,0.00009747817,0.000203093,0.001655064,0.0007682951,0.002133112,0.0007258976,0.0009106675,0.000532634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008115713,"about_ca_system_score_gemma":0.001366451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004470387,"about_ca_topic_score_gemma":0.003711337,"domain_scores_codex":[0.998336,0.000815008,0.0003772093,0.0001690219,0.0002110578,0.00009176231],"domain_scores_gemma":[0.9965328,0.0009237279,0.0009780163,0.0002441579,0.001036869,0.0002843428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000617317,0.0001904329,0.5127482,0.0007697371,0.00006856088,0.0007305309,0.001308909,0.0008897498,0.006711683,0.01242178,0.009998333,0.4535446],"study_design_scores_gemma":[0.00004422558,0.0009853876,0.9038925,0.001264618,0.0001175216,0.007050187,0.002789054,0.00248383,0.002072366,0.0127745,0.06643964,0.00008604806],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6604204,0.1633247,0.08208099,0.02358478,0.001397235,0.00144686,0.003704756,0.0003157484,0.06372451],"genre_scores_gemma":[0.9109064,0.03453115,0.04515363,0.002120539,0.0011119,0.0003186355,0.002870404,0.00006227393,0.002925063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004470387,"threshold_uncertainty_score":0.01894081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1177601972499049,"score_gpt":0.3778439076248274,"score_spread":0.2600837103749226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}