{"id":"W2105219838","doi":"10.1534/genetics.113.156836","title":"Synthetic Lethal Targeting of Superoxide Dismutase 1 Selectively Kills <i>RAD54B</i>-Deficient Colorectal Cancer Cells","year":2013,"lang":"en","type":"article","venue":"Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Synthetic lethality; Biology; Cancer cell; DNA damage; Genetics; Gene; Cancer; SOD1; Somatic cell; Context (archaeology); DNA repair; Saccharomyces cerevisiae; Genome instability; Cancer research; DNA; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001175161,0.0002903346,0.0003824486,0.000311144,0.0001200648,0.0002846257,0.0001518667,0.0001649734,0.0007306561],"category_scores_gemma":[0.0001234789,0.0001323281,0.0002607007,0.0003053032,0.0001296244,0.00008499159,0.0001699398,0.0003291696,0.0002096759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003144685,"about_ca_system_score_gemma":0.0001642077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000870776,"about_ca_topic_score_gemma":0.001638753,"domain_scores_codex":[0.9998919,0.00001342614,0.00001368596,0.00002847165,0.00003759842,0.00001498083],"domain_scores_gemma":[0.9999127,0.00001485991,0.00003778396,0.00001355707,0.00000718718,0.00001387295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004366359,0.00001048385,0.0004118185,0.00002061497,0.000006857796,0.00002095947,0.000003146889,0.0001822685,0.9983218,0.0000349561,0.00003465408,0.0009086758],"study_design_scores_gemma":[0.00001211602,0.0001922885,0.008088755,0.000003970961,0.00002055767,0.0002181561,0.00001628648,0.002266943,0.9875054,0.0000502083,0.001620447,0.000004681631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929483,0.0005344891,0.004240521,0.00006016105,0.00001050059,0.00003025973,0.001408282,0.0002005034,0.0005669312],"genre_scores_gemma":[0.9908676,0.0005078496,0.005196093,0.00003504516,0.000002451188,0.00003277633,0.002493956,0.00003239825,0.0008318253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000870776,"threshold_uncertainty_score":0.002444327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005200203196807106,"score_gpt":0.2176637828565788,"score_spread":0.2124635796597717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}