{"id":"W2105232821","doi":"10.3899/jrheum.090273","title":"Unresponsiveness to Colchicine Therapy in Patients with Familial Mediterranean Fever Homozygous for the M694V Mutation","year":2009,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Familial Mediterranean fever; MEFV; Colchicine; Medicine; Amyloidosis; Internal medicine; Allele; Gastroenterology; Proteinuria; Genotype; Compound heterozygosity; Mutation; Gene mutation; Disease; Genetics; Gene; Kidney; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003882565,0.00009581597,0.0001663098,0.00005942388,0.00008076042,0.000006694159,0.0002429685,0.00006155268,0.00000435684],"category_scores_gemma":[0.0001108003,0.00004793855,0.00004649523,0.00008632113,0.00005757387,0.000005572494,0.00001296904,0.00009269018,0.000001026563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000873617,"about_ca_system_score_gemma":0.00006772086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001877347,"about_ca_topic_score_gemma":0.00007583386,"domain_scores_codex":[0.9992843,0.000127564,0.0002585794,0.00007125672,0.0001011345,0.0001571792],"domain_scores_gemma":[0.9993448,0.00009477857,0.0001691779,0.0001578835,0.0002109611,0.00002235485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1854694,0.001599064,0.3515818,0.00007102863,0.001177358,0.00003397569,0.01793756,0.01749489,0.1289807,0.0004360311,0.0152166,0.2800016],"study_design_scores_gemma":[0.02531679,0.02043805,0.9160753,0.0001430092,0.0001069617,0.001000063,0.002522142,0.000134584,0.02131054,0.0006181497,0.01183957,0.0004948362],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955693,0.0004561025,0.001596968,0.001824253,0.0001949712,0.0003433696,0.000002682592,0.000001351622,0.00001100678],"genre_scores_gemma":[0.9987395,0.0003151146,0.00005662825,0.0008259651,0.00001704234,0.000005318652,0.00001042389,0.000008738893,0.00002129986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5644935,"threshold_uncertainty_score":0.1954877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006687306842840531,"score_gpt":0.2393713036892188,"score_spread":0.2326839968463782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}