{"id":"W2105232821","doi":"10.3899/jrheum.090273","title":"Unresponsiveness to Colchicine Therapy in Patients with Familial Mediterranean Fever Homozygous for the M694V Mutation","year":2009,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Familial Mediterranean fever; MEFV; Colchicine; Medicine; Amyloidosis; Internal medicine; Allele; Gastroenterology; Proteinuria; Genotype; Compound heterozygosity; Mutation; Gene mutation; Disease; Genetics; Gene; Kidney; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002786583,0.0002442817,0.0003089725,0.0005317154,0.0002718411,0.0001896819,0.0001301841,0.0003486396,0.0008435959],"category_scores_gemma":[0.001515752,0.0001285316,0.0001823946,0.0002804307,0.0002167477,0.000158791,0.0001147915,0.000216675,0.0001145527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001207756,"about_ca_system_score_gemma":0.00009040307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004402632,"about_ca_topic_score_gemma":0.0004981974,"domain_scores_codex":[0.9997041,0.0001080257,0.00003387601,0.00006071508,0.00004905905,0.00004428027],"domain_scores_gemma":[0.9994023,0.0002275309,0.0002082434,0.00002977712,0.00003655554,0.00009561513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000449641,0.00004599548,0.9908164,0.00001477604,0.00003506805,0.002156473,0.0001073226,0.00006916971,0.002658797,0.000009183344,0.00008499603,0.003552141],"study_design_scores_gemma":[0.00003183665,0.0006232211,0.9820437,0.000009484506,0.00003098583,0.01580151,0.0001760572,0.0003206406,0.0007313396,0.00002534818,0.0002013708,0.000004353968],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996638,0.0001392353,0.00004353119,0.00001698445,0.000002095552,0.000002056306,0.00001659099,0.000002635365,0.0001130069],"genre_scores_gemma":[0.9998658,0.00003024648,0.0000330352,0.00001279857,0.00000667606,0.000001518872,0.00002641156,7.09759e-7,0.00002281751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008435959,"threshold_uncertainty_score":0.002822101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006687306842840531,"score_gpt":0.2393713036892188,"score_spread":0.2326839968463782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}